Isolation and NMR Spectral Assignments of 18-Glycyrrhetinic acid-3-O-D-glucuronide and 18-Glycyrrhetinic acid
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2014, Vol 4, Issue 1
Abstract
Two olenane triterpenes, 18β-glycyrrhetinic acid-3-O-β-D-glucuronide and 18β-glycyrrhetinic acid were obtained from the acid hydrolysis of 18β-glycyrrhetinic acid-3-O-β-D-glucuronopyranosyl-(1→2)-β-D-glucuronide (Glycyrrhizic acid or Glycyrrhizin), a triterpene glucuronide isolated from the commercial extract of the roots of Glycyrrhia glabra. The complete 1H and 13C NMR assignments of the two triterpenes 18β-glycyrrhetinic acid-3-O-β-D-glucuronide and 18β-glycyrrhetinic acid were achieved on the basis of extensive 1D and 2D NMR (1H and 13C, COSY, HSQC, and HMBC) as well as mass spectral data.
Authors and Affiliations
Venkata Sai Prakash Chaturvedula , Oliver Yu
Keywords
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