Luteolin isolate from the methanol extract identified as the singlecarbon compound responsible for broad antiulcer activities of Cassia singueana Leaves
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2014, Vol 4, Issue 10
Abstract
The results of earlier studies by my team of researchers demonstrated the wide spectrum of in vivo gastro-protective effects of the methanol extract of Cassia singueana leaves (MECSL) in rats. The crude extract exhibited profound potency against experimentally-induced ulcerative lesions in various gastric ulcer induction models (pyloric ligation/histamine, indomethacin and ethanol-mediated stomach ulcers) in rats. The activities of the extract thus, authenticated the claim of high folkloric efficacy of the plant leaves in diverse chronic peptic ulcer therapies in Northern Nigeria. Bioassay-guided fraction using column chromatography, thin layer chromatography (TLC) and indomethacin treatment afforded the isolation of the bioactive compound. A further TLC purification of this pure compound facilitated the isolation of the single-carbon antiulcer agent from MECSL. Structural and molecular elucidation of this active principle with Nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry enabled its identification as luteolin. Luteolin is a known compound which is safe and possesses multiplicity of effects against gastric ulceration. The results of this study provide indications for conducting clinical trials with luteolin as a potential sole antiulcer agent.
Authors and Affiliations
O. J. Ode, I. U. Asuzu
Keywords
Related Articles
- EP ID EP142430
- DOI -
- Views 83
- Downloads 0
Brief Communication Thombotic Trombocytopenic Purpura: Allergic Reaction to Plasma Proteins During Therapeutic Apheresis
Thrombotic Thrombocytopenic Purpura (TTP) is a raredisordercharacterized by microangiopathichemolysis with thrombosis. The golds tandard of treatment is the rapeutic plasma exchangewhichreplenishesthedep...
[b] Assessment of Awareness and Knowledge About Package Inserts Amongst Medical Students: A Questionnaire Based Study[/b]
Pathogenesis, Diagnosis and Treatment of Vaginitis and Cervicitis in Clinical Practice
Vulvovaginitis results with the loss of Lactobacillus-dominated normal vaginal flora,with the sexual activity pathogenic organisms are introduced into the vagina. Lactobacillus maintain normal vaginal pH of 3.5,a...
A Comparative Study of Metformin plus Sulfonylureas Versus Metforminalone for its efficacy in Type 2 Diabetes patients
The objective of the study was to compare the efficacy of combination containing Metformin plus Sulfonylureas (MET+GLI/GLIB) and to determine whether combination of Sulfonylureas had clinically remarkable benefit over Me...
Substance Abuse among Adolescents: 2. Prevalence and Patterns of Cigarette smoking among senior secondary school students in Abraka, Delta State, Nigeria
: Cigarette smoking is an important health hazard and a major preventable cause of morbidity and mortality. More young people are getting involved in tobacco use in Nigeria. This is of great concern. This study...