MANAGEMENT OF HYPERPROLACTINEMIA
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2013, Vol 2, Issue 10
Abstract
Hyperprolactenemia refers to the consistent presence of abnormally high levels of prolactin in the blood after ruling out the physiological causes of prolactin hypersecretion. Prolactin is mainly concerned with breast development during pregnancy and induction of lactation. It is secreted in a pulsatile manner, and increases with sleep, stress, pregnancy, chest wall stimulation or trauma. Therefore, hyperprolactenemia could be physiological, pathological or pharmacological. The clinical presentation is varied and may manifest as oligomenorrhoea, amenorrhoea, infertility (as a result of the above), decreased libido and habitual abortion. Premenopausal women may also present with galactorrhoea which requires the presence of both oestrogen and prolactin. Hyperprolactenemia may cause osteopenia and also hyperandrogenism Before giving treatment due consideration must be given to an infertile women regarding her desire for pregnancy. There are three treatment options :- Medical, Surgical and Radiotherapy. All have their pros and cons but medical treatment should be started as soon as possible. It also helps at the time of surgery as it may induce tumor regression enabling resection of a greater part of the tumor leading to better control of prolactin levels.
Authors and Affiliations
Minie Mohan
Keywords
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