N-ACETYLCYSTEINE EFFECT ON GENTAMICIN INDUCED NEPHROTOXICITY IN ANIMAL MODELS
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2016, Vol 5, Issue 42
Abstract
BACKGROUND Gentamicin exerts a unique pharmacokinetic effect on renal physiology and its use at high dose or prolonged treatment requires monitoring of kidney function test. Antioxidants has been claimed to have nephroprotective potential and hence antioxidant compound, N-acetylcysteine (NAC) has been used in renal impairment; however, its efficacy is not very well documented. Therefore, the present study has been undertaken to evaluate the role of antioxidant (NAC) in impaired kidney function due to high dose Gentamicin in rat models. Gentamicin at the dose of 80 mg/kg b.w. intramuscularly was given in 18 adult healthy albino rats for 10 days and varying doses of antioxidant NAC (20 and 40 mg/kg) were given orally for 3 wks. starting from day 5 of the experiment. Blood urea and creatinine levels were measured on day 5, 10 and after completion of treatment of NAC and histopathology examination conducted. Intramuscular injection of high dose of Gentamicin significantly produced biochemical signs of nephrotoxicity. Serum creatinine levels were significantly lowered in NAC treated group compared to the control group. The group treated with NAC 40 mg/kg for 3 wks. had significantly lowered renal biochemical parameters and histopathological features compared to control.
Authors and Affiliations
Laishram Devi, Usham Meetei, Khuraijam Devi, Victoria
Keywords
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- EP ID EP164751
- DOI 10.14260/jemds/2016/612
- Views 110
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