NEUROPROTECTIVE ACTIVITY OF HIBISCUS ROSA-SINESIS FLOWERS IN SCOPOLAMINE INDUCED COGNITIVE DECLINE RATS
Journal Title: Int J of Pharm Rev& Res - Year 2016, Vol 6, Issue 1
Abstract
ABSTRACT Aim of the present study is Petroleum ether extract of Hibiscus rosa-sinesis (PETECHB) was evaluated in scopolamine induced cognitive decline rat model for its nootropic and neuroprotective activity. Effect on spatial working memory, spatial reference memory and spatial working-reference memory was evaluated by Rectangular maze, Morris water maze, Pole climbing apparatus, and locomotor activity respectively. Neuroprotective effects of PETEHB was studied by assaying acetylcholinesterase, TBARS, DPPH and CAT levels in the brain of nootropic rats. The PETEHB (150 and 300 mg/kg) was found to cause significant increase in spatial working memory (P < 0.05), spatial reference memory (P < 0.001) and spatial working-reference (P < 0.001) in retention trials on Rectangular maze, Morris water maze and Pole climbing apparatus respectively. Whereas significant decrease in acetylcholinesterase activity (P < 0.05), MDA levels (P < 0.001), and significant increase in DPPH, CAT levels was observed in animals treated with PETECP (150 and 300 mg/kg) compared to nootropic control group. The present data indicates that Hibiscus rosa-sinesis flowers tenders protection against Scopolamine induced cognitive decline rats and merits the need for further studies to elucidate its mode of action. Key words: Hibiscus rosa-sinesis, Neuroprotectivity, Nootropic, Alzheimer’s, Morris water maze, Rectangular maze, Pole climbing apparatus, Locomotor activity.
Authors and Affiliations
Akhila Hanumakonda* and Vydehi Maheshwaram
Keywords
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