PENTOXIFYLLINE: A THERAPEUTIC REMEDY FOR OPTIC NEUROPATHIES
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2013, Vol 2, Issue 20
Abstract
[b] PURPOSE[/b]: To evaluate effect of oral pentoxifylline in optic neuropathies of different etiologies. [b]METHOD[/b]: Thirty two patients (42 eyes) with different stages of optic atrophy of less than 1 year duration were selected for the study. They were randomly divided into two groups. Treatment group was given oral pentoxifylline 16-18mg/kg body weight administered in two equal divided doses. Patients in Control group were kept on placebo for minimum of 6 months. Best corrected visual acuity (BCVA) was recorded at one, three and 6 months using Snellen’s visual acuity charts. [b]RESULTS[/b]: All patients completed minimum 6 month of treatment. In Treatment group, 03 eyes had pre-treatment visual acuity of light perception (PL), which at the end of 6 months of treatment attained BCVA of 20/80, 20/200, and finger counting at 2 feet respectively. Another 4 eyes in the treatment group had pre-treatment BCVA of no light perception (NPL) which showed no improvement after 6 months of therapy. In control group 7 eyes with PL or NPL showed no improvement. Among rest of the patients, in treatment group pre-treatment and 6 month post-treatment median BCVA were 1.35 ± 0.44 and 0.75 ± 0.45 respectively (p=0.002, CI = -0.9 to -0.25), while in control group, pre-treatment and post treatment median BCVA was 1.32 ± 0.42 and 1.31 ± 0.42 respectively (p=0.157, CI = -0. 5 to 0.0), respectively. [b]CONCLUSION[/b]: Oral Pentoxifylline causes functional improvement as suggested by improved BCVA, without causing any gross structural changes in the optic disc. It has no effect on pupillary reaction as well.
Authors and Affiliations
Perwez Khan, Lubna Khan, Upma Awasthi, Abadan Khan, Zia Siddique, Ramesh Chand
Keywords
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