Pharmacognostic studies on Taxus baccata L.: A brilliant source of Anti-cancer agents
Journal Title: Pakistan Journal of Pharmaceutical Sciences - Year 2016, Vol 29, Issue 1
Abstract
The present investigation was undertaken to establish standardization profile of Taxus baccata L. with the help of pharmacognostic parameters, which is not done before. T. baccata (Taxaceae), is native to Europe, is an evergreen needle-leaved tree, growing up to 28 m high. A large number of phytochemicals like taxoids viz. taxusin, baccatin, baccatin, lignans, flavanoids, steroids, paclitaxel and sugar derivatives have been isolated from it. For the treatment of different types of cancer like ovarian and breast cancers, Kaposi’s sarcoma and lung cancers Paclitaxel (taxol) has been approved. Paclitaxel is also under clinical trial for remedy of number of other cancers in combination with other chemotherapeutic medications. Pharmacognostical and preliminary phytochemical screening of T. baccata will be useful to authenticate and avoid adulteration in the raw material. The diagnostic microscopic characters, physiochemical data and FTIR will be useful in the development of monograph.
Authors and Affiliations
Muhammad Asif , Ghazala H. Rizwani , Hina Zahid , Zahid Khan , Rao Qasim
Keywords
Related Articles
- EP ID EP133313
- DOI -
- Views 81
- Downloads 0
Unpredictable chronic mild stress induced behavioral deficits: A comparative study in male and female rats
Stress is an important precipitant factor for depression. Changes in various body systems that occur in depression are similar to those observed in response to stress. Chronic stress may alter behavioral, neurochem...
Comparative research for the dietary pattern of patients with esophageal cancer at different developing stages and the daily intake of vitamin A, E and Beta-carotene
This paper discusses the different stages of normal esophageal’s developing to esophageal cancer, and the difference among dietary patterns of patients with esophageal cancer and acceptable daily intake of vitamin...
Effectiveness and Safety of a 10mg Warfarin Initiation Nomogram in Asian Population
Anticoagulant responses to warfarin vary among patients, based on genetic factors, diet, concomitant medications, and disease state. We evaluated the effectiveness and safety of a 10mg warfarin initiation nomogram...
Clinical effects of immunotherapy of DC-CIK combined with chemotherapy in treating patients with metastatic breast cancer
This study aimed to analyze the clinical effects of dendritic cell (DC) and cytokine-induced killer (CIK) immunotherapy combined with chemotherapy on patients with metastatic breast cancer. Twenty patients were inc...
Analysis on diagnostic value of esophageal electrophysiological examination for positive atropine test
To discuss the cause of positive atropine test and the possible reason for false positive atropine test, providing a certain aids for clinical diagnosis and treatment. Eighty patients, conducted atropine test due t...