Pharmacological studies of anti diarrhoeal activity of Casuarina equisetifolia (L.) in experimental animals
Journal Title: Asian J of Pharm Sci & Tech - Year 2011, Vol 1, Issue 1
Abstract
ABSTRACT The purpose of the present study was to evaluate scientifically the anti-diarrhoeal effects of ethanolic (90%) extract of Casuarina equisetifolia Linn (EECE) was studied against castor oil-induced-diarrhoea model in rats. Antidiarrhoeal activity of 90% ethanol extract of Casuarina equisetifolia was investigated in this study using castor oil-induced-diarrhoea, enteropooling and Small intestinal transit models in rats. The weight and volume of intestinal content induced by castor oil were studied by enteropooling method. Standard drug diphenoxylate (5 ml/kg, p.o) was significant reductions in fecal output and frequency of droppings whereas EECE at the doses of 200 and 400 mg/kg p.o significantly (P<0.001) reduced the castor-oil induced frequency and consistency of diarrhoea and enteropooling. The gastrointestinal transit rate was expressed as the percentage of the longest distance travelled by the charcoal divided by the total length of the small intestine. EECE at the doses of 200 and 400 mg/kg significantly inhibited (P<0.001) the castor oil induced charcoal meal transit. The EECE showed marked reduction in the number of diarrhoea stools and the reduction in the weight and volume of the intestinal contents, as well as a modest reduction in intestinal transit. The results obtained establish the efficacy and substantiate the folklore claim as an anti- diarrheal agent. Further studies are needed to completely understand the mechanism of anti-diarrhoeal action of Casuarina equisetifolia Linn. Keywords: Antidiarrhoeal Activity, Casuarina equisetifolia L., Traditional medicine, Castor Oil- induced diarrhoea, Enteropooling Method, Small intestinal transit.
Authors and Affiliations
K. K. Senthil Kumar
Keywords
Related Articles
- EP ID EP144052
- DOI -
- Views 153
- Downloads 0
BIOANALYTICAL METHOD FOR THE QUANTITATIVE ESTIMATION OF FROVATRIPTAN IN RABBIT PLASMA BY LC–MS/MS AND ITS APPLICATION TO A PHARMACOKINETIC STUDY
ABSTRACT Liquid chromatography–tandem mass spectrometry was used to develop a simple, sensitive and rapid method for the quantitative determination of frovatriptan in rabbit plasma using frovatriptan d3 as intern...
ACCURACY OF MALARIA DIAGNOSIS AND PRESCRIBING PATTERNS FOR FEBRILE UNDERFIVES IN AN AREA WITH DECLINING MALARIA BURDEN, NORTHEASTERN TANZANIA
ABSTRACT This study examined the accuracy of clinical diagnosis and rapid malaria diagnostic test (mRDT) for the prediction of malaria; and the patterns of prescription for febrile underfives in a setting with re...
A NEW CORNUCOPIA IN TOPICAL DRUG DELIVERY: MICROSPONGE TECHNOLOGY
ABSTRACT The expanding arena of emerging drugs, increased sensitivity to clinical outcomes and healthcare costs are driving the need for alternative drug delivery methods and devices. The drug delivery technology...
THERAPEUTIC PROPERTIES OF MEDICINAL PLANTS: A REVIEW OF PLANTS WITH HYPOLIPIDEMIC, HEMOSTATIC, FIBRINOLYTIC AND ANTICOAGULANT EFFECTS (PART 1)
ABSTRACT The recent studies showed that many plants possessed cardiovascular effects. This review was designed to cover the hypolipidemic, fibrinolytic anti platelet aggregating and antioxidant effects of the med...
DESIGN AND IN-VITRO-IN-VIVO CHARACTERIZATION OF BUCCAL TABLETS OF SIMVASTATIN
ABSTRACT The main objective of present study is to develop Bucco adhesive bilayer tablets of Simvastatin using mucoadhesive polymers. Simvastatin has short biological half-life (3h), high first-pass metabolism an...