Pharmacological studies of anti diarrhoeal activity of Casuarina equisetifolia (L.) in experimental animals
Journal Title: Asian J of Pharm Sci & Tech - Year 2011, Vol 1, Issue 1
Abstract
ABSTRACT The purpose of the present study was to evaluate scientifically the anti-diarrhoeal effects of ethanolic (90%) extract of Casuarina equisetifolia Linn (EECE) was studied against castor oil-induced-diarrhoea model in rats. Antidiarrhoeal activity of 90% ethanol extract of Casuarina equisetifolia was investigated in this study using castor oil-induced-diarrhoea, enteropooling and Small intestinal transit models in rats. The weight and volume of intestinal content induced by castor oil were studied by enteropooling method. Standard drug diphenoxylate (5 ml/kg, p.o) was significant reductions in fecal output and frequency of droppings whereas EECE at the doses of 200 and 400 mg/kg p.o significantly (P<0.001) reduced the castor-oil induced frequency and consistency of diarrhoea and enteropooling. The gastrointestinal transit rate was expressed as the percentage of the longest distance travelled by the charcoal divided by the total length of the small intestine. EECE at the doses of 200 and 400 mg/kg significantly inhibited (P<0.001) the castor oil induced charcoal meal transit. The EECE showed marked reduction in the number of diarrhoea stools and the reduction in the weight and volume of the intestinal contents, as well as a modest reduction in intestinal transit. The results obtained establish the efficacy and substantiate the folklore claim as an anti- diarrheal agent. Further studies are needed to completely understand the mechanism of anti-diarrhoeal action of Casuarina equisetifolia Linn. Keywords: Antidiarrhoeal Activity, Casuarina equisetifolia L., Traditional medicine, Castor Oil- induced diarrhoea, Enteropooling Method, Small intestinal transit.
Authors and Affiliations
K. K. Senthil Kumar
Keywords
Related Articles
- EP ID EP144052
- DOI -
- Views 147
- Downloads 0
Study on phytochemical profile and Anti-ulcerogenic effect of Casuarina equisetifolia (L.)
ABSTRACT Casuarina equisetifolia (L.) is a member of the Casuarinaceae. It is common along the coast on beaches, rocky coasts, limestone outcroppings, dry hillsides and open forests in both wet and dry zones from...
DESIGN AND IN-VITRO-IN-VIVO CHARACTERIZATION OF BUCCAL TABLETS OF SIMVASTATIN
ABSTRACT The main objective of present study is to develop Bucco adhesive bilayer tablets of Simvastatin using mucoadhesive polymers. Simvastatin has short biological half-life (3h), high first-pass metabolism an...
ANTOBODY RESPONSE OF ACHYRANTHES ASPERA LINN. TO AEROMONAS HYDROPHILA IN OREOCHROMIS MOSSAMBICUS
ABSTRACT Fish is the cheapest and most easily digestible animal protein and was obtained from natural sources from time immemorial for consumption by human beings. Fish culture can be taken as a major economic ac...
SAMPLE PREPARATION IN BIO ANALYTICAL METHODS - A REVIEW
ABSTRACT This article reviews the recent developments in Bio-Analytical sample preparation techniques and gives an update on basic principles, Applications and comparative discussion on the advantages and limita...
THE PHARMACOLOGICAL AND THERAPEUTIC IMPORTANCE OF AGRIMONIA EUPATORIA- A REVIEW
ABSTRACT The phytochemical analysis of Agrimonia eupatoria revealed the presence of carbohydrates, glycosides, tannins, terpenoids, phenolic compounds (flavonoids), agrimony, agrimony lactone, oils and many other...