Pharmacological studies of anti diarrhoeal activity of Casuarina equisetifolia (L.) in experimental animals
Journal Title: Asian J of Pharm Sci & Tech - Year 2011, Vol 1, Issue 1
Abstract
ABSTRACT The purpose of the present study was to evaluate scientifically the anti-diarrhoeal effects of ethanolic (90%) extract of Casuarina equisetifolia Linn (EECE) was studied against castor oil-induced-diarrhoea model in rats. Antidiarrhoeal activity of 90% ethanol extract of Casuarina equisetifolia was investigated in this study using castor oil-induced-diarrhoea, enteropooling and Small intestinal transit models in rats. The weight and volume of intestinal content induced by castor oil were studied by enteropooling method. Standard drug diphenoxylate (5 ml/kg, p.o) was significant reductions in fecal output and frequency of droppings whereas EECE at the doses of 200 and 400 mg/kg p.o significantly (P<0.001) reduced the castor-oil induced frequency and consistency of diarrhoea and enteropooling. The gastrointestinal transit rate was expressed as the percentage of the longest distance travelled by the charcoal divided by the total length of the small intestine. EECE at the doses of 200 and 400 mg/kg significantly inhibited (P<0.001) the castor oil induced charcoal meal transit. The EECE showed marked reduction in the number of diarrhoea stools and the reduction in the weight and volume of the intestinal contents, as well as a modest reduction in intestinal transit. The results obtained establish the efficacy and substantiate the folklore claim as an anti- diarrheal agent. Further studies are needed to completely understand the mechanism of anti-diarrhoeal action of Casuarina equisetifolia Linn. Keywords: Antidiarrhoeal Activity, Casuarina equisetifolia L., Traditional medicine, Castor Oil- induced diarrhoea, Enteropooling Method, Small intestinal transit.
Authors and Affiliations
K. K. Senthil Kumar
Keywords
Related Articles
- EP ID EP144052
- DOI -
- Views 172
- Downloads 0
REVIEW OF ELECTRO PHOTONIC CAPTURING (EPC) METHOD TO MEASURE THE ACTIVITY OF THE AUTONOMOUS NERVOUS SYSTEM
ABSTRACT EPC is a convenient and easy to use device, easily allows examining patients with various pathologies and, therefore, offers a wide range of applications. To evaluate the scale and scope of implementing...
SCREENING OF EFFICACY OF VARIOUS EXTRACTS OF CARICA PAPAYA L. FOR POTENTIAL ANTIFERTILITY ACTIVITY
ABSTRACT This study was undertaken due to the popular belief in most of the Asian countries that the unripe fruit eaten during early months of pregnancy can lead to miscarriage. The aim of the present study was t...
THERAPEUTIC PROPERTIES OF MEDICINAL PLANTS: A REVIEW OF THEIR DETOXIFICATION CAPACITY AND PROTECTIVE EFFECTS (PART 1)
ABSTRACT Modern research has shown that a wide range of plants can neutralize or detoxify toxins and protect respiratory, urinary, hepatic and neural systems from the toxic effects of drugs and chemicals. These p...
BIOANALYTICAL METHOD FOR THE QUANTITATIVE ESTIMATION OF FROVATRIPTAN IN RABBIT PLASMA BY LC–MS/MS AND ITS APPLICATION TO A PHARMACOKINETIC STUDY
ABSTRACT Liquid chromatography–tandem mass spectrometry was used to develop a simple, sensitive and rapid method for the quantitative determination of frovatriptan in rabbit plasma using frovatriptan d3 as intern...
DECOLOURIZATION OF REACTIVE DYES USING BACTERIA ISOLATED FROM TEXTILE DYE EFFLUENT
ABSTRACT The Bacillus licheniformis and Pseudomonas putida were isolated from Industrial effluent and was tested for decolorization activity against commercially important dyes such Reactive red 195, Reactive Yel...