Physicochemical Analysis of Dashanga Agada – An Ayurvedic Formulation
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2013, Vol 3, Issue 6
Abstract
Background: Standardization of herbal formulation is essential to assess the quality of drugs. This article reports on standardization of Dashanga Agada, an Ayurvedic formulation indicated in various poisonous and non-poisonous conditions by Ayurvedic as well as traditional Keralian Visha Vaidyas. Aims: Physicochemical standardization of Dashanga Agada.Methodology: Dashanga Agada was prepared as per classics in Gullika (Tablet) form. In-house preparation has been standardized on the basis of organoleptic characters, physical characteristics, Physico-chemical properties, High performance thin layer chromatography (HPTLC) and Thin layer chromatography (TLC) methods. Results: pH of Dashanga Agada at 5% aqueous solution was 4.58%w/v, Loss on drying at 1100C 10.57% w/w, Total Ash 8% w/w, Acid Insoluble Ash 2.45% w/w, Water Soluble Ash 23.85% w/w, Alcohol Soluble Extractive 15.87% w/w, Methanol Soluble Extractive 23.66% w/w. Fluorescence analysis results indicated no fluorescent material in formulation. Microbial limit test (MLT) showed there was no growth of organisms after 24hrs of incubation as per IP. Thin Layer chromatographic analysis (TLC) showed 10 and 11 picks at 254nm and 366nm respectively.Conclusion: The set parameters can be used as reference standards for the quality control.
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