PREVALENCE OF VIRULENCE FACTORS AMONG ENTEROCOCCAL ISOLATES IN A TERTIARY CARE HOSPITAL
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2016, Vol 5, Issue 51
Abstract
BACKGROUND Enterococci are a notoriously resistant pathogen capable of producing an array of virulence factors. Biofilm production, gelatinase and haemolysin are the three potential virulence factors of Enterococci. Gelatinase and haemolysin producing strains of Enterococcus have been shown to cause severe infections in animal models. Biofilm production is associated with the persistence of Enterococcus in the medical indwelling devices and is extremely difficult to treat them. AIMS To know the prevalence of gelatinase, haemolysin and biofilm formation among clinical isolates of enterococci. MATERIALS AND METHODS A total of 76 enterococcal isolates obtained from various clinical samples during the period from July 2015 to October 2015 were included in the study. All the isolates were speciated and tested for the presence of virulence factors which include gelatinase, haemolysin and biofilm production. RESULTS Out of 76 enterococcal isolates, E. faecalis were 31 (41%) and E. faecium were 45 (59%). Haemolysis was observed in 26 (34.2%) isolates. Gelatinase was observed in 14 (18.4%) isolates. Biofilm formation was observed in 28 (36.8%) isolates. Biofilm production was more predominant in E. faecium isolates, whereas gelatinase production was more common in E. faecalis. CONCLUSION The study concludes that virulence determinants have been widely prevalent in enterococci isolates from clinical specimens. Prompt evaluation for identification of various virulence factors should be done, which in turn will help in the appropriate management of the patients.
Authors and Affiliations
Kadevari , Manisha , Sreekanth , Gundela
Keywords
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- EP ID EP159624
- DOI 10.14260/jemds/2016/768
- Views 84
- Downloads 0
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