PREVENTION OF HYPOTENSION DURING PROPOFOL INDUCTION: A COMPARISON OF PRELOADING WITH RINGER LACTATE AND INTRAVENOUS EPHEDRINE
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2013, Vol 2, Issue 35
Abstract
The induction of general anaesthesia with propofol, however, has been associated with a decrease in systolic arterial blood pressure. Various measures to prevent hypotension include preloading with fluids (colloids and crystalloids) and use of vasopressors including ephedrine, dopamine, dobutamine, and metaraminol. The aim of the present study was to compare the three different regimes for the prevention of hypotension during induction of anaesthesia. [b]MATERIALS [/b] [b]AND METHODS[/b]: Ninety patients, classified as ASA physical status I or II, male/female, aged 20-50 years, body weight 45-85 kg, scheduled for various elective surgeries under general anaesthesia gave written informed consent to participate in this study. Patients were randomly allocated into one of three groups of 30 patients each to receive either normal saline Group C, ephedrine 70μg/kg, or Group E 10ml/kg Ringer Lactate Group RL prior to induction of anaesthesia with propofol (2mg/kg). Parameters analyzed were: heart rate and systemic arterial pressure noninvasively before induction, after propofol administration, immediate post intubation and then at 3min, 5min and at 10 post intubation. [b]RESULTS[/b]: In all the groups there was an increase in the systemic arterial pressure post intubation; ephedrine> RL > control group. On comparing the groups at varied intervals the decrease was statistically significant in control group. (P<0.00).On comparing ephedrine group with RL decrease was statistically significant in the ephedrine group at 10mins. (P<0.01). [b]CONCLUSION[/b]: We concluded, preoperative administration of ephedrine failed to prevent propofol-induced hypotension, but preoperative volume loading with 10ml/kg of ringer lactate successfully antagonised it, hence provide more haemodynamic stability
Authors and Affiliations
Amit Agarwal, Kanchan Sharma, Shobha Parashar, Ashok Sharma, Manisha Meena
Keywords
Related Articles
- EP ID EP111882
- DOI 10.14260/jemds/1188
- Views 138
- Downloads 0
HER-2 ONCOPROTEIN EXPRESSION IN UROTHELIAL CARCINOMA
BACKGROUND Low grade non-muscle invasive transitional cell carcinoma is associated with repeated recurrences and progression to high grade tumour. Non-muscle invasive transitional cell carcinoma is associated with poor o...
MAGNETIC RESONANCE SPECTROSCOPY IN CHILDREN WITH NON-ACUTE NEUROLOGICAL ILLNESS
BACKGROUND The causes of non-acute neurological illness presenting as developmental delay and regression of attained milestones are frequently unknown, and clinicians and families can be frustrated by the lack of neuroim...
ASSOCIATION OF OBESITY WITH OSTEOARTHRITIS OF KNEE JOINT IN FEMALES
[b] Introduction[/b]: Osteoarthritis is a common degenerative disease of knee joints 1. Knee osteoarthritis is the most common type. Obesity is the main preventive risk factor that has been identified in large j...
INTERSTITIAL BRACHYTHERAPY IN THE MANAGEMENT OF UTERINE CERVICAL CANCER- SINGLE INSTITUTIONAL STUDY
BACKGROUND The objective of this study is to report the clinical outcome of patients with carcinoma cervix treated by radiation therapy including brachytherapy (BT), using template based Interstitial Brachytherapy (ISBT)...
CORRELATION OF NECK CIRCUMFERENCE AND DYSLIPIDAEMIA
BACKGROUND Anthropometric measures have been used for screening patients for cardiovascular abnormalities and metabolic syndrome since many years. The measurements generally used are height, weight, waist and hip circumf...