Relationship between cytological grading of breast cancers and lymph node metastasis
Journal Title: International Journal of Medical Science and Public Health - Year 2014, Vol 3, Issue 8
Abstract
Background: Breast cancer is the second most common type of cancer and the second leading cause of cancer related deaths in females. Since a less invasive pre-operative diagnosis is always preferred to open biopsy, fine needle aspiration cytology has been frequently used to decide the benign or malignant nature of particular breast lesions. But many studies have shown that this technique can provide additional information about the intrinsic features of the tumours as well as their prognosis. Grading of breast carcinoma, while the tumour is still in vivo, would be the most ideal and desirable situation, as it would be helpful in the selection of patients for appropriate therapy. Aims & Objective: (i) To evaluate and compare the cytograding of breast cancers using Robinson’s and Mouriquand’s grading methods. (ii) To evaluate the relationship between cytograding of breast cancers and lymph node metastasis. Materials and Methods: A 5-year retrospective (from Oct 2000 to Sept 2005) and 1-year prospective study (from Oct 2005to Oct 2006). A total of 110 fine-needle aspiration cytology (FNAC) cases of breast cancers were graded by Robinson’s and Mouriquand’s grading methods followed by comparison of the two methods. Relationship between grading and lymph node metastasis was evaluated. Results: By Robinson’s method, 28 (25.45%) cases were grade I, 46 (41.81%) grade II and 36 (32.72%) were grade III whereas using Mouriquand’s method, 28 (25.45%), 42 (38.18%) and 40 (36.36%) cases were graded as grade I, II, and III respectively. A high degree of concordance was observed between the two grading methods (90.9%). A highly significant relationship between the scores obtained by two methods was also observed (P=0.004). By Robinson’s method, Grade I, II and III tumours had lymph node involvement in 3.57%, 6.52% and 47.22% of cases respectively whereas by Mouriquand’s method, Grade I, II and III tumours had lymph node involvement in 3.57%, 7.14% and 42.5% of cases respectively. Although both grading systems showed significant relationship with lymph node involvement but Robinson’s grading was a much better predictor of lymph node metastasis. Our study showed that greater cell dissociation was associated with higher incidence of regional lymph node metastasis. A highly significant relationship was observed between cell dissociation and lymph node involvement (p=0.00000). Conclusion: A comprehensive cytological grading of breast cancers is possible by using Robinson’s and Mouriquand’s method. A high degree of concordance was observed between the two methods but Robinson’s grading system was found to be easier and better because of more objective set of criteria and easy reproducibility. Cytological grading of breast cancers is a strong predictor of lymph nodal metastasis and greater cell dissociation is associated with higher incidence of regional lymph node metastasis
Authors and Affiliations
Farooq Wani, Subhash Bhardwaj, Dinesh Kumar, Parvej Katoch, Altaf Hussain
Keywords
Related Articles
- EP ID EP132780
- DOI 10.5455/ijmsph.2014.190520141
- Views 81
- Downloads 0
Knowledge and attitude among late adolescents (16-19 years old) toward human immunodeficiency virus/acquired immune deficiency syndrome in Al-Khobar, Saudi Arabia
Background: Inadequate knowledge, negative attitude, and risky practices are major hindrances to preventing the spread of human immunodeficiency virus (HIV). Objective: This study aimed to assess knowledge and attitude a...
Blood donation awareness and beliefs among medical and nursing students
Background: College students form a large, healthy, and active population of potential blood donors; their recruitment and retention would immensely help meet the demand of safe blood. The knowledge and practice of blo...
Identifying and addressing the determinants that affect successful control of diabetes mellitus type II
Background: Various life variables are known not essential to the advancement of type 2 diabetes including weight, absence of adequate physical action, terrible eating routine, anxiety, and urbanization. A number of diet...
Attitude regarding reproductive health among the second PUC students from the colleges of Bengaluru city
Background: India has the second largest population in the world. Majority of the health problems in women are due to the reproductive health. A positive attitude towards reproductive health is very important to our youn...
Risk factors of breast cancer among the primary health-care attendees in Eastern Saudi Arabia
Background: Breast cancer has been the most common cancer among the Saudi female subjects for the last decades. Objective: To screen primary health-care (PHC) attendees for the risk factors of breast cancer in Easter...