Role of Ki-67 in acromegalic patients with hyperprolactinemia: Retrospective analysis in 61 Chinese Patients
Journal Title: Pakistan Journal of Pharmaceutical Sciences - Year 2015, Vol 28, Issue 2
Abstract
To evaluate the specific characteristics in acromegalic patients with hyperprolactinemia by analyzing the differences between patients with different Ki-67 values. Between 2002 and 2010, a set of data on 61 patients undergoing transsphenoidal surgery was available at the Department of Neurosurgery, Provincial Hospital Affiliated to Shandong University. Patients were divided into Ki-67 ≥3% group and <3% group. A retrospective analysis of clinical, hormonal, immunohistochemical, and imaging was observed in all patients. There were no significant differences in age, gender, tumor size and apoplexy between the two groups. Time interval in Ki-67 ≥3% group was longer than <3% group (P=0.037). Patients in Ki-67 ≥3% group had a higher rate of invasiveness (P=0.048), higher incidences of diabetes mellitus (P=0.036), coarse facial features (P=0.048), large hands and feet (P=0.003), higher GH levels (P<0.05), higher diabetes insipidus rate (P<0.001), and more frequent recurrence (P=0.011) than Ki-67 <3% group. Patients with higher Ki-67 value harbored longer time interval, more aggressive tumors, more acromegaly manifestations, higher GH level, and higher recurrence than patients with lower Ki-67 value.
Authors and Affiliations
Cheng Huan , Guihua Cui , Chao Lu , Xin Qu , Tao Han
Keywords
Related Articles
- EP ID EP122061
- DOI -
- Views 105
- Downloads 0
In vitro release of ketoprofen suppositories using the USP basket and the flow-through cell dissolution methods
In order to study the release characteristics of ketoprofen suppositories under the hydrodynamic environment generated by USP Apparatus 1 and 4, the dissolution profiles of the Mexican reference product (100 mg) we...
Antipyretic activity of hydro-alcoholic extracts of Moringa oleifera in rabbits
Pyrexia and inflammation are indicatives of various disorders. Modern medicines are available for treatment of pyrexia, but they have few side effects. Several studies are ongoing Worldwide to search natural antipy...
An old dietary regimen as a new lifestyle change for Gastro esophageal reflux disease: A pilot study
Treatment of gastro esophageal reflux disease (GERD) is becoming a challenge for medical profession. Proton pump inhibitors (PPIs) are commonly recommended but many disadvantages of these drugs are being reported,...
Leucocytes show improvement growth on pha polymer surface
Polyhydroxyalkanoate (PHA) from one fermentation process shows diverse physical properties when extracted using different methods. Pseudomonas aeruginosa strain has been previously isolated from the Egyptian ecosystem wa...
Clinical efficacy of polyherbal formulation Eezpain spray for muscular pain relief
The topical herbal formulation Eezpain spray consisting of natural ingredients that have been clinically proved for its analgesic and anti-inflammatory activity. The designed formulation on application knee and wri...