Screening of antioxidant phytoextracts of Canarium odontophyllum (Miq.) leaves in vitro
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2014, Vol 4, Issue 12
Abstract
This is the first study to investigate for the antioxidant efficacy and to detect selected phytochemicals in leaf extracts of Canarium odontophyllum (Miq.). The aqueous, methanol and acetone extracts at 12.5 μg/ml, 25 μg/ml and 50 μg/ml, were screened for their in vitro antioxidant activity using FRAP assay with reference to ascorbic acid. Phytoconstituent screening test was conducted using the standard reagents. All the leaf extracts from Canarium odontophyllum were found to exhibit dose-dependent antioxidant potential but acetone extract displayed the highest antioxidant capacity of 89.49 3.64μM FeSO4.7H2O, 181.46 5.54 μM FeSO4.7H2O and 355.26 16.62 μM FeSO4.7H2O at 12.5 μg/ml, 25 μg/ml and 50 μg/ml, respectively whereas aqueous extract has the lowest antioxidant power of 33.87 0.97 μM FeSO4.7H2O (12.5 μg/ml), 73.60 2.78 μM FeSO4.7H2O (25 μg/ml) and 140.29 0.28 μM FeSO4.7H2O (50 μg/ml). Methanol extract, on the other hand, exhibited moderate antioxidant activity which was significantly higher (p< 0.05) compared to aqueous extract but no significant difference to that of acetone extract. Despite its highest antioxidant potential with respect to aqueous and methanol extract, the standard agent (ascorbic acid) displayed almost twice the antioxidant power of the acetone extract. The phytoconstituents in the leaf extracts of Canarium odontophyllum were shown to be terpenoid, tannin and flavonoid.
Authors and Affiliations
Dayang Fredalina Basri , Kai Yen Heng 1 , Chan Kok Meng 1 and Ahmad Rohi Ghazali 1
Keywords
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