SERINE PHOSPHORYLATION EFFECT ON SECONDARY STRUCTURE PREDICTION OF INTRINSICALLY UNSTRUCTURED AND ORDERED STRUCTURED PENTAPEPTIDES BY RAMACHANDRAN ANALYSIS
Journal Title: International Journal of Engineering Sciences & Research Technology - Year 30, Vol 5, Issue 7
Abstract
Many proteins associated with cell signalling pathways are often targets of post-translational modifications such as phosphorylation, glycosylation, ubiquitination, nitrosylation, methylation, acetylation, lipidation and proteolysis. Such modifications can lead to the induction or disruption of secondary structural elements of the modified protein. This paper describes the structural behaviour of a set of intrinsically disordered peptides (IDP) and ordered structured peptides (OP) modified by phosphorylation on a serine residue. These pentapeptides (IDP and OP) derived from fragmentation of proteins from different organisms. Ramachandran analysis revealed that both, IDP and OP, have an overall propensity for α-helical structure that is greatest in IDP and non-existent in OP cluster conformations. Phosphorylation of OP caused a decrease in the helical propensity in the serine phosphorylated residues, whereas for IDP with high disorder tendency, the opposite was observed and phosphorylation engendered alpha left-handed helical propensity.
Authors and Affiliations
Simon M. Longela
Keywords
Related Articles
- EP ID EP107099
- DOI 10.5281/zenodo.57943
- Views 59
- Downloads 0
A Brief Survey on Frequent Patterns Mining of Uncertain Data
Frequent pattern mining is the extraction of interested collection of items from dataset. Frequent Itemset mining plays an important role in the mining of various patterns and is in demand in many real life applic...
Effect of Friction Stir Welding on Mechanical Properties of Dissimilar Aluminium Aa6061 and Aa2014 Alloy Joints
In present study, Dissimilar Friction Stir Butt Welds made of 2014 and 6061 Aluminium alloys were performed with various welding parameter. The present study deals with the influence of Square Profile Pin on Frict...
Analysis of Single phase inverter with Boost Converter and Photovoltaic module
Now a day’s renewable energy like solar, wind becomes very popular. To convert solar energy into electrical energy inverter is an one of the main components. The performance of inverter is different for different...
THE INFLUENCE OF PROCESS PARAMETERS ON MICROHARDNESS AND MECHANICAL PROPERTIES OF FSW ALUMINIUM 5083 ALLOY BUTT JOINT
Recently the air craft and military industries widely have been using aluminium alloys particularly because of their fine strength to weight ratio. However in compare with steels they represent welding difficulties and...
[sub][/sub] IMPLEMENTATION ISSUES OF ADDITIVE TECHNOLOGIES
Based on the analysis of the results of activities aimed at the development of three-dimensional printing in Kazakhstan, highlighted the alleged problems of the successful implementation of additive technologies i...