SERINE PHOSPHORYLATION EFFECT ON SECONDARY STRUCTURE PREDICTION OF INTRINSICALLY UNSTRUCTURED AND ORDERED STRUCTURED PENTAPEPTIDES BY RAMACHANDRAN ANALYSIS
Journal Title: International Journal of Engineering Sciences & Research Technology - Year 30, Vol 5, Issue 7
Abstract
Many proteins associated with cell signalling pathways are often targets of post-translational modifications such as phosphorylation, glycosylation, ubiquitination, nitrosylation, methylation, acetylation, lipidation and proteolysis. Such modifications can lead to the induction or disruption of secondary structural elements of the modified protein. This paper describes the structural behaviour of a set of intrinsically disordered peptides (IDP) and ordered structured peptides (OP) modified by phosphorylation on a serine residue. These pentapeptides (IDP and OP) derived from fragmentation of proteins from different organisms. Ramachandran analysis revealed that both, IDP and OP, have an overall propensity for α-helical structure that is greatest in IDP and non-existent in OP cluster conformations. Phosphorylation of OP caused a decrease in the helical propensity in the serine phosphorylated residues, whereas for IDP with high disorder tendency, the opposite was observed and phosphorylation engendered alpha left-handed helical propensity.
Authors and Affiliations
Simon M. Longela
Keywords
Related Articles
- EP ID EP107099
- DOI 10.5281/zenodo.57943
- Views 71
- Downloads 0
A New Approach for Detecting Outliers in Data Streams
In modern years, data streams have become an increasingly important research area, where as data stream refers to continuous flow of data and it is a process of extracting knowledge structure from continuous, rapi...
DE NOISING OF MEDICAL IMAGES BY USING WAVELET AND GAUSSIAN LAPLACIAN MODELS
In this proposed method De noise the image by using image processing techniques. The de noise is very main important thing in medical image processing. After de noised only the image can we propose any other stage...
Designing Mobility using Distance Routing Effect Algorithm
An ad-hoc network signifies a solution designed for a specific problem or task and it is an independent network that provides usually temporary peer-to-peer connectivity without relying on a complete network infr...
Image Compression using DCT and DWT-Technique
This paper provides comparison between two image compression technique such as DCT and DWT. Discrete Cosine Transform (DCT) and Discrete Wavelet Transform (DWT) are the most commonly used transformation. DCT has high e...
Studies on Performance of Metallic wick using Kerosene and Biodiesel
Cotton wicks are normally used for heating stove and lightening lamps. It is felt that frequent changing of cotton wicks can be avoided by developing metallic wicks using powder metallurgy techniques. Conventional...