Serum Total Bilirubin levels in Diabetic Retinopathy - A case control study
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2014, Vol 4, Issue 8
Abstract
ABTRACT: Introduction/ Back ground Diabetic retinopathy (DR), ending with loss of vision is one of the microvascular complications of Diabetes Mellitus (DM). Bilirubin, with potent antioxidant and anti-inflammatory properties on the vasculature, has been linked to vaso-occlusive disorders. Objectives: To evaluate the Serum Total Bilirubin levels in diabetic patients with retinopathy, diabetic without complications & to compare and correlate the same parameters with age & gender matched clinically healthy controls. Materials and Methods Study group consisted, total of 75 subjects divided into three groups - Group I (DR), Group II (Type 2 DM without retinopathy) & Group III (clinically proven healthy controls). Estimation of Biochemical parameters were done by standard methods. ResultsComparison of biochemical parameters were made between the three groups. We observed significant increase in FBS, HbA1c & significant decrease in serum Total Bilirubin with p value <0.001 in Group I when compared to Group II & Group III. Negative correlations of Total Bilirubin with FBS & with HbA1c were observed in Group I. Conclusion Poor Glycemic control, oxidative stress in diabetes can cause profound damage to the vital organs. Negative association of Serum Total Bilirubin with FBS & HbA1c in Group I & Group II when compared to Group III. Therefore estimation of Serum Total Bilirubin is a less expensive parameter, which helps clinicians in effectively controlling and preventing the onset & progression of complications of diabetes such as diabetic retinopathy.
Authors and Affiliations
Dr. Prabhavathi. K , Mrs. Mamatha Kunder , Dr. Shashidhar K. N , Dr. Harish R
Keywords
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