SNEDDON’S SYNDROME
Journal Title: Journal of IMAB - Annual Proceeding (Scientific Papers) - Year 2008, Vol 14, Issue 1
Abstract
Sneddon’s syndrome is usually characterized by the association of an ischemic cerebrovascular disease and a widespread livedo reticularis. The incidence of Sneddon syndrome is 4/1000 000. We present 42-year-old woman with livedo reticularis, recurrence ischaemic cerebrovascular accidents, two repetitive miscarriages and positive anti-2GPi antibodies. Skin biopsy specimens reveal inflammatory changes of small- to medium-sized arteries and subendothelial proliferation and fibrosis. The diagnosis Sneddon syndrome is confirmed by skin biopsy, and MR evidence. We suggest that anti-2GPi antibodies may be pathophysiologically related to the clinical manifestation observed in some patients with Sneddon syndrome.
Authors and Affiliations
Valentin Valtchev, Virginia Simeonova, Dimitar Gospodinov, Ivelina Yordanova, Valentina Dimitrova, Verka Pavlova, E. Konova, Savelina Popovska, Boyko Stamenov
Keywords
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- EP ID EP115613
- DOI 10.5272/jimab.14-1-2010.72
- Views 123
- Downloads 0
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