Sorafenib in renal cell carcinoma
Journal Title: Pakistan Journal of Pharmaceutical Sciences - Year 2014, Vol 27, Issue 1
Abstract
Cancer is among most important causes of death in recent decades. Whoever the renal cell carcinoma incidence is low but it seems it is more complicated than the other cancers in terms of pathophysiology and treatments. The purpose of this work is to provide an overview and also deeper insight to renal cell carcinoma and the steps which have been taken to reach more specific treatment and target therapy, in this type of cancer by developing most effective agents such as Sorafenib. To achieve this goal hundreds of research paper and published work has been overviewed and due to limitation of space in a paper just focus in most important points on renal cell carcinoma, treatment of RCC and clinical development of Sorafenib. The information presented this paper shows the advanced of human knowledge to provide more efficient drug in treatment of some complicated cancer such as RCC in promising much better future to fight killing disease.
Authors and Affiliations
Ehsan Taghizadeh Davoudi , Mohamed Ibrahim bin Noordin , Hamid Akbari Javar , Ali Kadivar , Bahare Sabeti
Correction of iron deficiency anemia in pregnancy and its effects on Superoxide dismutase
Iron deficiency anemia (IDA) affects not only the hematological parameters but also disturb the oxidative balance of body. In pregnancy, this is much more considerable as oxidative stress is considered to be one of the p...
Efficacy of herbal coded Hepcon on drug induced hepatitis in experimental animals through histopathological and biochemical analysis
Drug-induced liver injury is the leading cause for more than 50 percent of cases of acute liver failure. This study was conducted on herbo-mineral formulation “Hepcon” to evaluate its hepatoprotective effects in dr...
Mining of protein based biomarkers for type 2 diabetes mellitus
Diabetes mellitus in general and Type 2 Diabetes (T2D) in particular, are very complex diseases with heterogeneous etiology. T2D results from the impaired secretion or action of the insulin with a clinical phenotype of p...
Evaluation of Medicago sativa L. sprouts as antihyperlipidemic and antihyperglycemic agent
Medicago sativa L. (Alfalfa) is traditionally used to treat diabetes. This study was designed to investigate the potential antihyperlipidemic and antihyperglycemic activity of M. sativa sprouts in streptozotocin (S...
Antitumor activity of a novel survivin siRNA
Breast cancer resistance to therapy can result from expression of antiapoptotic genes. Survivin is an antiapoptotic gene that is over expressed in most human tumors. RNA interference using short interfering RNA (si...