Stem Cell Therapy for Diabetes: Are We Close Enough?
Journal Title: Journal of Krishna Institute of Medical Sciences University - Year 2014, Vol 3, Issue 1
Abstract
Over the last few decades, understanding of the mechanismof cellular development has increased tremendously.The knowledge of the potential of stem/precursorcells in tissue engineering and cell therapy hasgained the popularity. In case of diabetes, the availabilityof the source of stem cells and the efficacy of theirisolation techniques for maximum yield of viable cellsto expand is an important issue which needs attention.Attempts to make beta cells from mouse embryonicstem cells (ES) and adult stem cells have been frustratingin part because too much has been expectedtoo soon. The problem with ES cells are that it is notknown whether these cells are truly similar to normalbeta cells or not and ethical issues surrounding them.ES cells is a major concern. Current claims about differentiation/ transdifferentiation of adult stem cells toinsulin producing cells has been demonstrated by manygroups. These adult stem cells are of enormous interestbecause of their general accessibility and lack ofethical issues. Also, adult stem cells are non immunocompatibleunless isolated from the same patientwhereas ethical and scientific issues surrounding embryonicand fetal stem cells hinder their widespreadimplementation. Therefore, much attention is now focusedon alternative sources of adult/postnatal stemcells.
Authors and Affiliations
Sachin S. Kadam
Keywords
Related Articles
- EP ID EP146874
- DOI -
- Views 124
- Downloads 0
An Interesting Case of Perforated Meckel’s Diverticulum
Meckel’s diverticulum is one of the common congenital anomalies of the small intestine that occurs in approximately 2% of population, with equal incidence in both sexes. It is caused by an incomplete obliteration of...
Relationship of Length of Clavicle and Crown-Rump Length
Background: When an incomplete fetal skeletoncomes to the Anatomy department for itsage estimation, it becomes difficult to arrive atthe age due to lack of information in most ofthe standard textbooks of Anatomy and Fore...
Significance of Mast Cell Density and Distribution in Various HistopathologicalLesions of Leprosy
Background: Leprosy also known as Hansen’s disease(HD), is a chronic infection caused by the Mycobacteriumleprae. Mast cells in leprosy have been investigatedin the recent past and are being examinedas a basis for future...
Human Salmonellosis Caused by Rare Salmonella Serotypes- Report of Two Cases
Salmonellosis is a global disease caused by bacteria belonging to the genus Salmonella. It is the most important food-borne pathogen which is transmitted usually through contaminated food and water and is responsible for...
Seroprevalence of Brucellosis among Blood Donors of Satara District, Maharashtra
Background: In endemic area for brucellosis background levels of antibodies are found in healthy populations. Aims & Objectives: The aim of this study was to determine the seroprevalence of anti-brucella antibodies a...