Studies on the Effect of Diet and Drug Therapies on Serum Ferritin, a Predictor of Type 2 Diabetes Mellitus
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2013, Vol 3, Issue 10
Abstract
Background and Objective: Epidemiological studies have established a link between serum ferritin concentration and type 2 diabetes. This work was carried out to ascertain the effect of therapeutic regimen on the earlier established links. Materials and Methods: Two hundred subjects comprising 130 type 2 diabetics and 70 apparently healthy controls were involved in the survey. Anthropometric parameters, fasting plasma glucose (FPG), Serum levels of ferritin, lipids and biochemical indicators of complications of type 2 DM were determined. Results were analysed statistically by ANOVA, and Pearson correlation. Results: Serum ferritin, showed a positive correlation with FPG, BP, TC, triglyceride, and TC/HDL ratio among diabetic subjects. With subjects classified based on the antidiabetic therapy, the mean serum ferritin level of the subjects on a combination therapy of drug and diet was significantly (p<0.05) lower than the level in those on either drug or diet alone. Serum ferritin level showed a positive correlation with TC and TC/HDL ratio, in diabetics on drug alone and with PFG, TC, and TG levels in subjects on diet alone but with none in subjects on a combined therapy. Conclusion: This finding suggests the need to take into due consideration type of diabetic medication when interpreting relationship between iron stores and diabetic risk
Authors and Affiliations
P. O. Okonkwo , Z. S. C. Okoye
Keywords
Related Articles
- EP ID EP120768
- DOI -
- Views 124
- Downloads 0
Auto-activated Thrombin Expression from Pichia pastorisSMD1168 Optimized by Plackett-Burman Design and Response Surface Methodology
Abstract: Recombinant thrombin (rThrombin) has been used topically as one component of fibrin sealant as the tissue adhesive. Recombinant prethrombin-2 is used as the precursor to generate rThrombin which is then activat...
Reducing Uveitic Glaucoma: therapeutic judgement is the key
Background: Uveitic glaucoma (UG) due to disease and /or therapeutics is an important reason for reduced vision. Different therapeutic regimen employed in uveitis can alter the course of UG. Purpose: Evaluatio...
Synthesis, characterization and antimicrobial evaluation of novel diethyl (2-phenylquinazolin-4-ylamino) (phenyl) methyl phosphate
A convenient and efficient one-pot reaction has been employed for the synthesis of new a-aminophosphonates 4a-4l via Kabachnik-Fields reaction in 89-95 % yields. In the procedure developed, equimolar quantities of...
Normative Data of Motor Free Visual Perception Test among Indian Children.
OBJECTIVE. The purpose of this study was to obtain normative data for Motor-Free Visual Perception Test (MVPT) in Chennai children.To find out the performance difference between genders. METHOD. Three Hundred and Thirty...
Theoretical Spectral investigation of a bioactive Benzenoid Isolated from Mimusops elengi
The bioactive aromatic aldehyde, vanillin (3-methoxy 4-hydroxy benzaldehyde) is isolated from stem bark of the medicinal plant Mimusops elengi for the first time. Elucidation of structure is achieved with the hel...