Study of Lipid Peroxidation and Antioxidant Status in Preeclampsia
Journal Title: Journal of Krishna Institute of Medical Sciences University - Year 2013, Vol 2, Issue 2
Abstract
Background: Preeclampsia is a pregnancy specificsyndrome, a leading cause of maternalfetalmorbidity and mortality. Free radicals leadto lipid peroxidation which is destructive innature and has been suggested as an aetiologicalfactor in preeclampsia. Aims and Objectives:To determine the role oxidative stress and levelof antioxidants in preeclampsia by estimationof malondialdehyde (MDA) (index of lipidperoxidation) and antioxidants such as uric acid,vitamin C, vitamin E and superoxide dismutase(SOD) in preeclampsia. Material and Methods:In present study 40 non pregnant women,40 normal pregnant women and 40 preeclampticwomen aged between 18-35 years were enrolled.Clinically diagnosed preeclampticwomen were compared with normal pregnantwomen of same gestational age and serum wasanalyzed for serum MDA, uric acid, vitamin Eand vitamin C and SOD. Statistical analysis wasdone by ANOVA followed by Tukeys multiplecomparison. Results: Serum MDA and uric acidlevels were significantly raised (P<0.01) inpreeclamptic women as compared to normalpregnant women and non pregnant women whileserum antioxidant vitamin E, vitamin C, andSOD levels were significantly decreased(P<0.01) in preeclamptic women and normalpregnant women as compared to non pregnantwomen. Conclusion: Increased levels of lipidperoxidation product (MDA) and depletion ofantioxidants such as vitamin E, vitamin C andSOD except uric acid in women with preeclampsiamay suggest that oxidative stress plays a keyrole in the genesis of endothelial dysfunctionand expression of preeclampsia. Adjuvantsupplementation of these antioxidants excepturic acid to the diet may minimize further progressionof preeclampsia.
Authors and Affiliations
Anjum Sayyed , Alka Sontakke
Keywords
Related Articles
- EP ID EP135851
- DOI -
- Views 66
- Downloads 0
Multidrug Resistance and Phage Pattern of Staphylococcus aureus in Pyoderma Cases
Background: Pyoderma is common in India and other tropical countries. Staphylococcus aureus is the commonest causative agent of pyoderma. Aims and Objectives: To know the antibiotic susceptibility and bacteriophage patte...
Morphometry and Relations of the Rectum to the Various Anatomical Landmarks: A Cadaveric Study
Background: The present study aimed to calculate the length of the rectum, its anterior peritoneal reflection and to assess the relations of the rectum to the various anatomical landmarks in cadavers. Also, to observe an...
Aspergilloma of Infra Orbital Nerve in an Immunocompetent Female: A Case Report
Aspergilloma of the paranasal sinus is a non-invasive form of aspergillosis. We report a 50 year old female with chief complaints of swelling in left infra orbital area without involving maxillary sinus. Computed tom...
Drug-Drug Interactions among Elderly Patients at Hospital Discharge: A Cross-Sectional Descriptive Study
Background: The presence of multiple comorbidities makes prescription of multiple drugs essential in the elderly. Thisis attended with an increased risk of potential drug-drug interactions (DDIs). Aim and objectives: To...
Alcohol Metabolizing Gene Polymorphisms as Genetic Biomarkers of Alcoholic Liver Disease Susceptibility and Severity: A Northeast India Patient Based Study
Background: Excessive alcohol consumption is associated with genetic predisposition to Alcoholic Liver Disease (ALD), but there is very limited data on both molecular and genetic aspects of ALD among the Northeast Indian...