STUDY OF LIPID PROFILE AND HOMOCYSTEINE LEVELS IN CASES OF CHRONIC KIDNEY DISEASE
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2014, Vol 3, Issue 26
Abstract
Chronic Kidney Disease (CKD) is a spectrum of different pathophysiologic processes associated with abnormal kidney function and a progressive decline in GFR. Chronic renal failure results in profound lipid disorder which stem largely from deregulation of high density lipoprotein (HDL) and triglyceride rich lipoprotein metabolism. Hypertriglyceridemia is the most common plasma lipid abnormality in patients with renal failure, coexisting with normal cholesterol level. Plasma homocysteine is strongly correlated to Glomerular Filtration rate. High homocysteine level leads to endothelial dysfunction. It is proposed to study lipid profile and homocysteine levels as attributable risk factors for chronic kidney disease. The objective of the study is to analyze the lipid profile and homocysteine levels in cases of chronic kidney disease. This study was carried out in patients admitted to Rama Medical College & Hospital Research Centre Mandhana, Kanpur. Study sample consisted of 40 patients of chronic renal disease with renal failure and 30 age and sex matched healthy controls. Patients were arbitrarily divided into 2 groups of patients >45 years age and patients<45 years age. Prevalence of lipid abnormalities and homocysteine levels, were studied in cases and controls. In study group A, dyslipidemia is found in 18 out of 20 cases (90%). Lipid levels significantly deranged in cases than controls. Dyslipidemia was present in 90% patients in study group A and 60% subjects in study group B. Our study highlights the fact that dyslipidemia and hyperhomocysteinemia are important risk factors in patients with chronic renal disease and these abnormalities are more prevalent in patients with end-stage renal disease and more in patients with other risk factors
Authors and Affiliations
Ajay Katiyar, Katiyar S. K
Keywords
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- EP ID EP153821
- DOI 10.14260/jemds/2014/2873
- Views 90
- Downloads 0
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