Synthesis, characterization and biological evaluation of some 5-methylpyrazine carbohydrazide based hydrazones
Journal Title: Pakistan Journal of Pharmaceutical Sciences - Year 2016, Vol 29, Issue 3
Abstract
Pyrazine carbohydrazide based hydrazones were synthesized starting from 5-methylpyrazine-2-carboxylic acid. The acid was first converted to its methyl ester, which on further treatment with hydrazine hydrate transformed to carbohydrazide. The carbohydrazide was treated with differently substituted aromatic carbonyl compounds giving hydrazones. Characterization of the synthesized compounds was carried out using modern spectroscopic techniques and unambiguously confirmed through X-ray crystallographic studies of compound 3d. The purity of the compounds was verified using elemental analysis. The target molecules were evaluated for urease inhibition, antioxidant and antimicrobial activity.
Authors and Affiliations
Mushtaq Ahmad , Shahid Hameed , Muhammad Nawaz Tahir , Muhammad Israr , Muhammad Anwar , Muhammad Abdullah Shah , Shad Ali Khan , Ghiasud Din
Keywords
Related Articles
- EP ID EP96231
- DOI -
- Views 97
- Downloads 0
Therapeutical effect of Radix Aconiti and Astragalus extracts on models of experimental bradycardia animal
The antibradycardia effect of extract of RAE (Radix Aconiti and Astragalus) on bradycardia animal models were evaluated. Bradycardia rat model was induced by amiodarone or propranolol, and sick sinus syndrome (SSS)...
Apolipoprotein E (Apo E) gene polymorphism and coronary heart disease in Asian populations
Apolipoprotein E (Apo E) is a basic component of very low-density lipoprotein (VLDL) and high-density lipoprotein (HDL). It plays an important role in the clearance of cholesterol from circulation, and thereby slow...
Antioxidant activity of simvastatin prevents ifosfamide-induced nephrotoxicity
Ifosfamide is an anticancer agent used largely in treatment of solid tumors. The mainstay dose-limiting toxicity of ifosfamide is nephrotoxicity. This is largely believde to be a result of ifosfamide-induced oxida...
Phenolic contents and antimicrobial activity of squirting cucumber (Ecballium elaterium) extracts against food-borne pathogens
Squirting cucumber (Ecballium elaterium), is an indigenous species of the south of Europe and the Mediterranean basin, sometimes cultivated for its use as a medicinal plant. This study compared phenolic contents in...
Purification and partial characterization of a Fructose-binding lectin from the leaves of Euphorbia helioscopia
A lectin was purified from leaves of Euphorbia helioscopia, by a combination of ion-exchange and gel filtration chromatography. On ion exchange using a DEAE- cellulose column in 0.2 M phosphate buffer, pH 7.2, the...