Synthesis, characterization and biological evaluation of tryptamine based benzamide derivatives Kiran
Journal Title: Pakistan Journal of Pharmaceutical Sciences - Year 2016, Vol 29, Issue 2
Abstract
Benzamides and tryptamine are biologically significant compounds, therefore, various benzamide analogous of tryptamine have been efficiently synthesized using tryptamine and different benzoyl chlorides, in order to find new biologically active compounds. The resulting products were then characterized by melting point determination, calculation of Rf values and LC-MS techniques. At last, structure activity relationship (SAR) of the synthesized compounds was evaluated against two microbial strains; Bacillus subtilis and Aspergillus niger. All the five prepared products have shown high yield, sharp characterization and significant resistance against the growth of tested microorganism, providing a new range of tryptamine based benzamide derivatives having significant antimicrobial activities.
Authors and Affiliations
Aftab , Kinza Aslam , Shazia Kousar , Muhammad Jawad Ul Hasan Nadeem
Keywords
Related Articles
- EP ID EP106995
- DOI -
- Views 90
- Downloads 0
Clinical evaluation of unani ear drops herbotic for earache
An ear infection (acute otitis media) is most often a bacterial or viral infection that affects the middle ear. Children as compared to adults are more are prone to infections. A study has been conducted on 200 pat...
Apoptosis-inducing effects of lentinan on the proliferation of human bladder cancer T24 cells
The aim of this study was to explore the effects of lentinan on the proliferation of human bladder cancer T24 cells and the mechanism regarding the inhibition of cell growth. When gene regulation technique was used...
Apomorphine induced conditioned place preference and sensitization is greater in rats exposed to unpredictable chronic mild stress
Abstract: CNS stimulants are the class of the drugs that may be used to get relief from depression. Apomorphine is a D1 and D2 receptor agonist with a CNS stimulatory effect used for the treatment of Parkinson’s di...
Cardiotonic and vasoconstriction effects of aqueous methanolic extract of Paspalidium flavidum L.
The cardiovascular activity of aqueous methanolic extract of Paspalidium flavidum L. was evaluated on isolated rabbit heart and aorta. Heart rates, force of contraction and perfusion pressure were assessed in the p...
Variation in pharmacokinetics of omeprazole and its metabolites by gender and CYP2C19 genotype in Pakistani male and female subjects
Pharmacokinetics (PK) variation of drugs in males and females may affect therapeutic effectiveness and safety. In current study the PK differences for omeprazole and its metabolites5-hydroxy-omeprazole and omeprazo...