Synthesis of Novel -2-(benzo[d][1,3] dioxol-5-yl)-5-fluoro-4-Phenylquinolines as Antibacterial Agents
Journal Title: International Journal of Engineering Sciences & Research Technology - Year 30, Vol 3, Issue 3
Abstract
A solution of 2-(benzo[d][1.3]dioxol-5-yl)-8-bromo-5-fluoro-4-phenylquinoline (4) react with boronic acid (5a-j) was heated at 100 0C for 12 hours in presence of Tetrakis(triphenylphosphine) palladium catalyst and K2CO3 as base in toluene:ethanol by the Suzuki-Miyaura cross-coupling reaction to give 2-(benzo[d][1,3] dioxol-5-yl)-5- fluoro-4-phenylquinolines derivatives(6a-j) in good yields.
Authors and Affiliations
T. Bhupal Reddy*
Keywords
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