The association of ghrelin -501A/C polymorphism with ghrelin and leptin levels in nonobese Saudi Population with type 2 diabetes mellitus
Journal Title: National Journal of Physiology, Pharmacy and Pharmacology - Year 2015, Vol 5, Issue 3
Abstract
Background: Saudi Arabia is one of the three of the world’s top 10 countries with the highest prevalence of diabetes mellitus. Ghrelin is a gut–brain endogenous peptide, and the genetic variations within the gene have been associated with the risk of developing type 2 diabetes mellitus (T2DM). Aims and Objective: To study the association of ghrelin -501A/C polymorphism with ghrelin and leptin levels in non-obese Saudi population with T2DM. Materials and Methods: Eighty unrelated Saudi subjects with diabetes and 56 healthy controls were recruited. Single nucleopeptide polymorphism (SNP) -501A/C (rs26802) of the ghrelin gene was genotyped by restriction fragment length polymorphism. Individuals were phenotypically characterized by body mass index, lipids, glucose, blood pressure, and leptin and ghrelin levels. Results: No significant difference in the -501A/C genotype distributions and allele frequency was observed between T2DM and control subjects (both P 4 0.05). Plasma ghrelin was negatively correlated with serum glucose, triglycerides, and total cholesterol in Saudi patients with diabetes. However, in control persons, no significant correlation was observed. In T2DM group, the 501A/A and 501A/C genotypes were associated significantly with lower plasma levels of ghrelin compared with C/C mutant homozygotes (P = 0.031), while the polymorphism was not associated with the lipid profile, leptin levels, or blood pressure. Conclusions: Although, the plasma levels of ghrelin were lower in A carriers compared with C/C mutant homozygotes and A carriers were associated with lower ghrelin levels, the ghrelin gene -501A/C polymorphism has no significant relationship with the susceptibility of T2DM in the Saudi patients with diabetes.
Authors and Affiliations
Tarek Mohamed Ali, Amany Salah Khalifa, Mohamed Noureldin H. Ali
Keywords
Related Articles
- EP ID EP138760
- DOI 10.5455/njppp.2015.5.1301201530
- Views 61
- Downloads 0
Peak expiratory flow rate in healthy school children
Background: Peak expiratory flow rate (PEFR) assesses the overall functional status of the respiratory system. Aims and Objectives: The aim of this study was to observe the PEFR in school going healthy children, in a tow...
Does visceral fat affect aerobic fitness in Indian adolescents of 18-19 years’ age group?
Background: Cardiovascular endurance tests are considered as one of the best methods for assessment of the individual’s health. Reduced aerobic fitness is seen in overweight and obese. Aerobic fitness is also reduced in...
Effect of Pranayama on respiratory endurance in young adults
Background: Pranayama is an integral part of Yoga with proven health benefits. Pranayama involves controlled breathing exercises and isometric contraction of respiratory muscles which have a major role in strengthening t...
Virtual screening of coformers and solubility test for glibenclamide cocrystallization
Background: The therapeutic effectiveness of active pharmaceutical ingredients (API) depends on their solubility. API, which has poorly soluble drugs, can cause low bioavailability. According to the biopharmaceutical cla...
Pattern of drug usage among medical students in Tumkur, Karnataka
Background: Scheduled drugs are also purchased without prescriptions, which is a cause for concern. Educational status is an important determinant of self-medication. Student drug use surveys provide an essential source...