The effect of methanolic extract of Dissotis rotundifolia on cadmium induced testicular damage in whistar rats.
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2014, Vol 4, Issue 7
Abstract
Cadmium is one of the most important toxic heavy metals, reported to have damage the testis of many mammals and Dissotis rotundifolia (Melastomaceae) Triana is known to have many uses in ethno-medicine. This present study was carried out to investigate the effect of Dissotis rotundifolia on the histology, sperm parameters, tissue antioxidant parameters on cadmium damaged testis and also to investigate its possible pro-fertility effect. Thirty (30) adult male Wistar albino rats divided into seven (7) groups were used in this research study. Group A received distilled water only, Group B received 2mg/kg b/w of cadmium only. Group C received 2mg/kg bw of cadmium and 50mg/kg bw of extract, Group D received 2mg/kg bw of cadimium and 300mg/kg bw of extract, Group E received 50mg/kg bw of exract only, Group F received 300mg/kg bw of extract only, Group G received 2mg/kg bw of cadmium and 300kg/mg bw of Vitamin E. Administration was done at 0800 hour daily foor 21days. Adminstration of Dissotis rotundifolia on cadmium induced testicular damage on Wistar rats showed signs of amelorative effect on the histology of testis, sperm parameters while on the normal testis it showed signs of pro-fertility effect, improving the histology of testis, enzyme antioxidant levels and sperm parameters at 50mg/kg per bw.
Authors and Affiliations
Makanjuola Victor Olufemi, Godam Elvis Tams, Ipinniwa Dolapo A
Keywords
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