The effect of topical cyclosporine A on tear film instability in patients with posterior blepharitis
Journal Title: Dicle Tıp Dergisi - Year 2013, Vol 40, Issue 3
Abstract
Objective: The aim of this study is to evaluate the efficacy of topical cyclosporine A (CsA) 0.05% (Restasis, Allergan Pharmaceuticals) in patients with posterior blepharitis. Methods: The study included 15 patients with posterior blepharitis. Topical CsA 0.05% (Restasis, Allergan Pharmaceuticals) was applied twice a daily for 2 months. They were evaluated at baseline and after treatment for subjective symptoms and objective signs including tear breakup time (BUT), Schirmer scores, conjunctival hyperemia, tarsal telangiectasis and Meibomian gland inclusions. Results: Fifteen patients completed the study. At the 2-month visit, the patients showed improvement in ocular symptom including burning, itching, conjunctival hyperemia (p<0.05; p<0.001; p<0.001, respectively).Topical administration of CsA provided improvement in Schirmer scores (p<0.001) Conclusion: Topical CsA was inducing an improvement in the ocular symptoms. Topical CsA 0.05% may be helpful in the treatment of posterior blepharitis. These findings should be further evaluated in large-scale. Key words: Posterior blepharitis, Cyclosporine A, Schirmer scores, breakup time
Authors and Affiliations
Onur Çatak, Ülkü Çeliker
Keywords
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- EP ID EP130855
- DOI 10.5798/diclemedj.0921.2013.03.0307
- Views 106
- Downloads 0
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