The protective effect of Echinacea spp. (Echinacea angustifolia and Echinacea purpurea) in a rat colitis model induced by acetic acid
Journal Title: Pakistan Journal of Pharmaceutical Sciences - Year 2014, Vol 27, Issue 6
Abstract
Ulcerative colitis (UC) is a chronic disease that causes an inflammatory condition in the colon. Several cytokines, including tumor necrosis factor alpha (TNF-α), interleukin 1 beta (IL-1β) and transforming growth factor beta (TGF-β) are crucial components of these inflammatory pathways. New therapeutic strategies are needed for improved clinical outcomes in UC and with less adverse effects. That is why alternative therapies such as herbal remedies are increasingly being used with favorable effects in the treatment of UC. Hence, in the present study, we aimed to evaluate the protective effect of Echinacea spp in an experimental rat colitis model induced by acetic acid (AA). Acetic acid was given via a rectal route to induce acute colitis in rats. Rats were placed in four groups: control, Echinacea, Echinacea-colitis and colitis. Tumor necrosis factor alpha, IL-1β and TGF-β levels were measured. Histopathological comparison of the groups was also performed. The disease activity index (DAI) was significantly higher in the colitis group compared to the control, Echinacea and Echinacea-colitis groups (p<0.001). There was no significant difference between the DAI of control, Echinacea and Echinacea-colitis groups (p>0.07). The inflammatory mediators IL-1β and TNF-α were significantly elevated in the colitis group compared to the other groups (p<0.007, <0.001 respectively). Therefore, Echinacea spp. may likely have some therapeutic favorable effects in the management of UC.
Authors and Affiliations
Zeynal Dogan , Bilal Ergul , Murat Sarikaya , Levent Filik , Mehmet Alparslan Gonultaş , Sema Hucumenoglu
Keywords
Related Articles
- EP ID EP163149
- DOI -
- Views 93
- Downloads 0
Gamma irradiation effects on the electrical properties of gold nanoparticles
Gold nanoparticles (AuNPs) offer a great promising in biomedical applications and their size has been shown to be important parameters that affect the particles uptake and cellular imbibition. The presented dielect...
Histopathologic changes in liver and kidney of male sprague dawley rats treated with extract of Cardiospermum halicacabum L.
In traditional medicine Cardiospermum halicacabum L. (Sapindeaceae) is used against various ailments such as rheumatism, nervous diseases, stiffness of the limbs and snakebite. Leaves are crushed and made into a te...
The effects of the leaf water extract of Struchium sparganophora (Linn.) Ktze asteraceae on the hematopoietic parameters and the organ system of rats
Struchium sparganophora, (Linn.) Asteraceae is a culinary herb consumed in the western part of Nigeria and it is known to have a nutritive value. This study was carried out to assess its’ effects on the hematopoiet...
Antagonistic bacteria from live corals, tuticorin coastal waters, Southeastern India
The objective of this study is to isolate and production of secondary metabolites with bioactive substances by coral reef (Acropora formosa and Favia palida) associated bacteria was carried out from the Tuticorin coastal...
An old dietary regimen as a new lifestyle change for Gastro esophageal reflux disease: A pilot studyAn old dietary regimen as a new lifestyle change for Gastro esophageal reflux disease: A pilot study
Treatment of gastro esophageal reflux disease (GERD) is becoming a challenge for medical profession. Proton pump inhibitors (PPIs) are commonly recommended but many disadvantages of these drugs are being reported,...