THE STUDY OF HEPATO-RENAL PROFILE ASSOCIATED WITH LEAD TOXICITY IN SPRAY PAINTERS
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2014, Vol 3, Issue 31
Abstract
Lead is a soft, dense, ductle, blue-grey metal. Lead is very stable and resistant to corrosion. It does not conduct electricity. Lead is effective shield against radiation. Lead present in natural deposits as ores, has been exploited extensively for commercial purposes because of its useful physiochemical profile. With years of knowledge on toxic effects of lead, it is used extensively in various products of common use found in and around our homes posing threat to humans. Occupational exposure to lead is entirely unregulated in many developing countries. The present study was carried out in spray painters to assess the magnitude of lead toxicity and also to highlight the subclinical toxicity with emphasis on renal and hepatic function. We have done a comparative study of blood lead levels, renal function parameters like serum creatinine, BUN, uric acid and liver function parameters like serum proteins, Albumin, Bilirubin AST, ALT in spray painters and nonpainters. In our present study the blood levels (p<0.001) were significantly increased as compared to the control group. Serum creatinine (p<0.001), BUN (p<0.001) and serum uric acid levels (p<0.004) were significantly increased in spray painters as compared to controls. Even though the mean values of liver function parameters were altered in spray painters as compared to controls, the range of values were within the acceptable limits for assay methods used. Currently there are some early and sensitive biochemical markers for detection of toxic effects of lead but they are still under epidemiological validation. The measured blood lead levels would be a good reference for monitoring the current status of lead toxicity, for evaluating the risk of progressive renal insufficiency and to apply possible lead chelating therapy early in clinical practice
Authors and Affiliations
Chuhitha S, Viswa Kumar, Chandra Mohan, Madhavi K, Prabhakar Rao
Keywords
Related Articles
- EP ID EP90276
- DOI 10.14260/jemds/2014/3109
- Views 100
- Downloads 0
BLOOD DONOR BEHAVIOUR AND BLOOD GROUP DISTRIBUTION IN CAMPS AND INSIDE INSTITUTIONS IN A PERIPHERAL/ MUNICIPAL AREA IN AP
BACKGROUND Blood donation has become a routine procedure all over India, meeting the needs of the entire population of 1.3 billion of India. It is indeed appreciable as the complications relating to blood donation and tr...
DISTAL PANCREATECTOMY IN THE SURGICAL TREATMENT OF PANCREATIC CANCER- A STUDY
BACKGROUND Improvements in the outcome of distal pancreatectomy (DP) for cancer is well accepted, but the series were small and heterogeneous. The aim of the present study was to assess perioperative and long-term outcom...
PREVALENCE OF DEPRESSION AMONG NEWLY DIAGNOSED MDR TUBERCULOSIS PATIENTS AT THE TIME OF REGISTRATION- AN EXPERIENCE FROM DOTS PLUS CENTRE
BACKGROUND MDR tuberculosis remains a leading chronic infection of lung and responsible for significant morbidity and mortality throughout the world and in India also. Depression is also a disorder of major public health...
AN ANALYTICAL STUDY OF ANATOMICAL VARIATIONS IN CLINICAL RHINOSINUSITIS
BACKGROUND The term ‘rhinosinusitis’ is defined as inflammation of the mucosa of the nose and paranasal sinuses. Anatomical variations are predisposing factors for causing rhinosinusitis. A precise knowledge of the anato...
A CROSS SECTIONAL STUDY ON CHOICE OF HEALTH CARE FACILITY IN RURAL AREAS OF KRISHNA DISTRICT
[b]BACKGROUND:[/b] Government is trying to deliver health services to as many numbers of people as possible. The extent to which these health services are utilized by the public is to be estimated. [b]OBJECTIVES: [/...