THE STUDY OF HEPATO-RENAL PROFILE ASSOCIATED WITH LEAD TOXICITY IN SPRAY PAINTERS
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2014, Vol 3, Issue 31
Abstract
Lead is a soft, dense, ductle, blue-grey metal. Lead is very stable and resistant to corrosion. It does not conduct electricity. Lead is effective shield against radiation. Lead present in natural deposits as ores, has been exploited extensively for commercial purposes because of its useful physiochemical profile. With years of knowledge on toxic effects of lead, it is used extensively in various products of common use found in and around our homes posing threat to humans. Occupational exposure to lead is entirely unregulated in many developing countries. The present study was carried out in spray painters to assess the magnitude of lead toxicity and also to highlight the subclinical toxicity with emphasis on renal and hepatic function. We have done a comparative study of blood lead levels, renal function parameters like serum creatinine, BUN, uric acid and liver function parameters like serum proteins, Albumin, Bilirubin AST, ALT in spray painters and nonpainters. In our present study the blood levels (p<0.001) were significantly increased as compared to the control group. Serum creatinine (p<0.001), BUN (p<0.001) and serum uric acid levels (p<0.004) were significantly increased in spray painters as compared to controls. Even though the mean values of liver function parameters were altered in spray painters as compared to controls, the range of values were within the acceptable limits for assay methods used. Currently there are some early and sensitive biochemical markers for detection of toxic effects of lead but they are still under epidemiological validation. The measured blood lead levels would be a good reference for monitoring the current status of lead toxicity, for evaluating the risk of progressive renal insufficiency and to apply possible lead chelating therapy early in clinical practice
Authors and Affiliations
Chuhitha S, Viswa Kumar, Chandra Mohan, Madhavi K, Prabhakar Rao
Keywords
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- EP ID EP90276
- DOI 10.14260/jemds/2014/3109
- Views 77
- Downloads 0
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