THROMBOCYTOPENIA IN HIV INFECTED PATIENTS AND ITS CORRELATION WITH CLINICAL AND IMMUNOLOGICAL STATUS

Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2013, Vol 2, Issue 27

Abstract

[b] BACKGROUND[/b]: India had an estimated 1.8-2.9 million HIV positive persons in 2007 with an estimated adult prevalence of 0.34% (0.25% -0.43%).1Thrombocytopenia may occur as a result of HIV infection itself, as sequel of HIV related opportunistic infections or malignancies or autoimmune disease or as a consequence of therapies used for HIV infection and associated conditions. This study was undertaken as more patients with thrombocytopenia are identified and not much studies regarding thrombocytopenia are reported from this part of world.[b] OBJECTIVE[/b]: To study prevalence of thrombocytopenia in HIV patients and to analyze isolated thrombocytopenia and as part of bi or pancytopenia in correlation with clinical (presence of AIDS) and immunological (CD4 count) status. [b]MATERIALS AND METHOD[/b]: 100 cases of HIV positive patients were studied over a period of 2 years. Data was collected by using pre-tested proforma and all patients were interviewed, detailed history was taken and detailed physical examination was carried out. Appropriate investigations were carried out like complete haemogram including peripheral smear, bone marrow biopsy whenever indicated, CD4 lymphocyte counts and so on. Anemia was defined as Hb< 13g/dl in males and <12g/dl in females (WHO); Leukopenia <4000/µl and thrombocytopenia as <1.5 lakh/µl. CD4 count was measured using flow cytometry. [b]RESULTS[/b]: Of 100 patients, 75 were males and 25 were females. Thrombocytopenia was prevalent in 23% of patients. The mean platelet count was 2.04 ± 0.92 lakh/µl. The mean platelet count in patients with CD4>200 was 2.33 ± 1.02 lakh/µl and with CD4<200 was 1.86 ± 0.80 lakh/µl (p= 0.5660); patients with AIDS was 2.40 ± 1.03 and without AIDS was 1.96 ± 0.88 lakh/µl (p=0.0638). Isolated thrombocytopenia occurred early in disease course without CDC defined AIDS (p= 0.0185) and with higher CD4 count (p= 0.0110). [b]CONCLUSIONS[/b]: Thrombocytopenia was present in 23% of patients and occurred independent of clinical or immunological status. Of note isolated thrombocytopenia was independent of and occurred early in disease course. Thrombocytopenia as part of bicytopenia or pancytopenia developed in advanced disease.

Authors and Affiliations

Harsha M. M, Chaithra S. P

Keywords

Related Articles

PANCYTOPENIA- A CLINICO-HAEMATOLOGICAL STUDY

BACKGROUND Pancytopenia is an important clinico-haematological entity encountered in our daily clinical practice. There are varying clinical patterns, treatment modalities and outcomes for pancytopenia. The severity of p...

PREVALENCE AND CLINICAL SIGNIFICANCE OF CARDIAC MURMURS IN NEONATES

BACKGROUND 5 to 8 in every 1000 live born babies have a cardiovascular malformation which presents in infancy, but most are asymptomatic at birth. The diagnosis is established only in 50% of cases by 1 month of age. The...

A CORRELATIVE CYTOLOGICAL AND HISTOPATHOLOGICAL STUDY ON LESIONS OF THYROID GLAND

BACKGROUND Thyroid gland is affected by a variety of pathological lesions. Fine needle aspiration cytology is a safe as well as cost effective tool in the study of thyroid lesions. Observations strongly support that Fine...

 TUBERCULOSIS AND RECURRENT POSTOPERATIVE WOUND INFECTION

 We report a case of post operative repeated wound infection due to Mycobacterium Tuberculosis. A 25 yr old woman presented to us with watery discharge from Caesarean section wound, done elsewhere 3 months ago....

MORPHOMETRIC STUDY OF THE BONY ORBIT

BACKGROUND Ocular surgeries and craniofacial surgeries require retrobulbar nerve blocks to produce anaesthesia and akinesia of the eyeball, which involves a risk to the optic nerve. The aim of this study is to determine...

Download PDF file
  • EP ID EP101031
  • DOI 10.14260/jemds/949
  • Views 121
  • Downloads 0

How To Cite

Harsha M. M, Chaithra S. P (2013).  THROMBOCYTOPENIA IN HIV INFECTED PATIENTS AND ITS CORRELATION WITH CLINICAL AND IMMUNOLOGICAL STATUS. Journal of Evolution of Medical and Dental Sciences, 2(27), 5035-5041. https://europub.co.uk/articles/-A-101031