THYMOQUINONE A POTENTIAL THERAPY FOR CEREBRAL OXIDATIVE STRESS
Journal Title: ASIAN JOURNAL OF NATURAL & APPLIED SCIENCES - Year 2012, Vol 1, Issue 2
Abstract
[b] Background[/b]:Subarachnoid hemorrhage is a common cerebrovascular event related to different etiologies, primarily aneurysmal rupture. Cerebral vasospasm is the main complication of subarachnoid hemorrhage leading to major morbidity and mortality. Various studies demonstrated that the vasoconstriction secondary to subarachnoid hemorrhage is induced by oxidative stress. It has been previously reported that Nigella sativa (NS) oil and thymoquinone (TQ), active constituent of NS, may prevent oxidative injury in various models. [b]Methods:[/b] The present study investigated the possible protective effects of thymoquinone (TQ), a compound derived from Nigella sativa with strong anti-oxidant properties, against oxidative stress in rat brains. Thirty two rats were randomly divided into four groups: A (control), B (TQ treated), C (oxidative stress induced) and D (TQ plus oxidative stress induced). Groups B, C and D received TQ (10 mg/kg body weight), PPr (8.51 mg/kg body weight) and (TQ 10 mg/kg + PPr 8.51 mg/kg) once a day orally by using intra-gastric intubation for 4 weeks, respectively. [b]Results:[/b] A stat of oxidative stress was induced in the rats proved by the production of significant elevation in brain lipid peroxidation, protein oxidation, DNA oxidation and DNA fragmentation, 338%, 132%, 87% and 103%, respectively; associated with a marked decrease in brain-reduced glutathione (GSH) and vitamin C content reaching 63% and 48%, respectively. In addition, PPr administration resulted in significant reduction in the acetylcholine esterase activity (53.6%) and enzymatic antioxidant parameters of brain. TQ treated groups showed significant change in oxidative stress biochemical markers, with almost total reversal towards the control group. [b]Conclusions:[/b]Thymoquinone treatment counteracted the induced oxidative stress in rats’ brain tissue by reducing the levels of peroxidation, and enhancing the activities of enzymatic and non-enzymatic antioxidants. Thymoquinone is a promising agent for the management of cerebrovascular ischemic insults like those resulting from vasospasm.
Authors and Affiliations
Bassem Y. Sheikh, Ahmed M. Mohamadin
Keywords
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