Use of Ketamine in Refractory Bronchospasm- A Study of 20 Cases
Journal Title: Journal of Krishna Institute of Medical Sciences University - Year 2013, Vol 2, Issue 2
Abstract
Objective: To study the effect of ketamine inpatients of severe wheezing due to bronchiolitiswho are refractory to the standard treatment.Methods: Prospective study including 104 childrenbetween 2 months to 2 years who presentedto us with severe wheezing due to bronchiolitis.Initially they were treated with humidifiedoxygen and adrenaline nebulisation. Childrenwith no response after 48 hours were givenintravenous ketamine as a bolus in dose of 1mg/kg. Patients were monitored with Uyanscore and oxygen saturation for 1 hour and thosewithout considerable improvement were givencontinuous infusion at 10 ìgm/kg/min. Results:104 patients were identified with severe wheezingdue to bronchiolitis during study period. 84(81%) patients responded well to standardtreatment. 20 (19%) patients who did not improvewere treated with ketamine. All patientsresponded to intravenous ketamine as bolus andshowed noticeable improvement in 1 hour withimprovement in scoring parameters. 14 (70%)patients had to be given infusion of ketamineand they were gradually weaned off the drip inan average of 15 hours. Conclusion: Use ofketamine in patients with severe wheezing dueto bronchiolitis who failed to respond to standardtreatment showed improvement which obviatedthe need for intubation and mechanicalventilation.
Authors and Affiliations
Vinayak Kshirsagar , Minhajuddin Ahmed , Sylvia Colaco
Keywords
Related Articles
- EP ID EP151480
- DOI -
- Views 68
- Downloads 0
In Vitro Biofilm Formation by Uropathogenic Bacteria and their Antibiotic Susceptibility Pattern
Background: Uropathogens have an ability to form biofilm in urinary tract. Microorganisms growing in biofilm are associated with chronic and recurrent UTI. They are highly resistant to a variety of antimicrobial agen...
Fetus Amorphous Acardious – A Case Report
Fetus amorphous acardious is a rare fetal malformation lacking a functional heart and bearing no resemblance to human embryos. The main differential diagnosis is with placental teratoma and is based on the degree of...
Speciation and Biofilm Production of Coagulase Negative Staphylococcal Isolates from Clinically Significant Specimens and their Antibiogram
Background: Coagulase Negative Staphylococci (CONS) are increasingly recognized as significant nosocomial pathogens. Their ability of biofilm formation and multiple drug resistance are causing serious human infection...
Oral Smokeless Tobacco Use with Special Reference to India
A Retrospective Study of Epidemiological and Clinical Patterns of ACDRs in Goa Medical College over a 6 Year Period
Background: Adverse Cutaneous Drug Reactions (ACDRs) account for 3% of all hospitalizations. The spectrum of drug reactions can be varied from mild to life threatening forms. Since the diagnosis of ACDR is purely clinica...