Neonatal Alloimmune Thrombocytopenia

Abstract

Neonatal alloimmune thrombocytopenia is the most common cause of immune-mediated thrombocytopenia in the newborn period. The disorder results from placental transfer of maternal alloantibodies directed against paternally inherited antigens carried on fetal platelets. While most cases are mild, some neonates have very low platelet counts associated with serious bleeding in hours to days following birth. The treatment for severely affected neonate is typically transfusion of compatible random donor platelets in addition to intravenous immunoglobulins. The diagnosis is confirmed by genotyping of parental platelet antigens and serological testing for maternal serum antibodies. We present a newborn with early onset symptomatic thrombocytopenia, in whom early clinical recognition and prompt therapeutic intervention resulted in the complete recovery. The importance of correct diagnosis for future pregnancies is emphasized.

Authors and Affiliations

Jelena Roganovic

Keywords

Related Articles

BMI-For-Age Cut-Off as an Indicator of Adiposity among In-School Children (Age 4-11 Years) in Obio/Akpor LGA, Rivers State, Nigeria

Background: Childhood overweight and obesity has been an issue of great concern to developing and developed nation where as degenerative underweight has ravaged the underdeveloped and war turn countries. Aim: This presen...

Immature Sacrococcygeal Teratoma with Microfoci of Yolk Sac Tumor in a Preterm Female NewbornIs the Surgical Resection Enough?

Sacrococcygeal teratoma (SCT) is the most common neoplasm in neonates and the most common germ cell tumor in children. SCT with malignant elements is very rare in infants. Prenatal diagnosis is of exceptional importance...

Cardiometabolic Risk Profile and its Relation with the Waist Circumference to Height Ratio in Turkish School-Age Children

Background: Obesity, cardiovascular diseases and diabetes have been rapidly increasing in pediatric age group all around the world. Therefore, cardiometabolic risk factors (CMRF) should be carefully screened beginning fr...

Acute Hemorrhagic Edema of Infancy: A New Observation

Acute Hemorrhagic Edema of Infancy is a is an uncommon benign cutaneous vacuities , It typically affects children between 4 and 24 months of age. It is characterized by large, target-like, and macular to purpuric plaques...

A Type 3 Klippel Feil Syndrome Case With Atrial Septal Defect and Atrial Septal Aneurysm

Klippel Feil syndrome (KFS) is a rare congenital disorder characterized by short neck due to abnormal fusion of cervical vertebrae, limited head and neck motion and low posterior hairline. We present a rare case of type...

Download PDF file
  • EP ID EP212890
  • DOI 10.19070/2572-7354-150002
  • Views 75
  • Downloads 0

How To Cite

Jelena Roganovic (2015). Neonatal Alloimmune Thrombocytopenia. International Journal of Pediatric Health Care & Advancements (IJPA), 2(1), 4-6. https://europub.co.uk/articles/-A-212890