Neonatal screening for congenital adrenal hyperplasia: 17-hydroxyprogesterone cut-off values based on birth weight

Journal Title: IP International Journal of Maxillofacial Imaging - Year 2018, Vol 5, Issue 2

Abstract

Introduction: Congenital adrenal hyperplasia (CAH) is an adrenal disorder, most commonly caused by 21- hydroxylase enzyme deficiency. Newborn screening for CAH is done by the measurement of 17-hydroxyprogesterone (17-OHP). Aim: To establish the reference limits of 17-OHP in newborns. Materials and Methods: The study was conducted at Sri Ramachandra Medical College and Research Institute (SRMC& RI), Chennai. The clinical data of 360 neonates delivered over a period of two years from January 2015 to December 2016 were retrospectively analyzed. The newborns were grouped according to birth-weight: G1: < 1>2250 g. Based on birth weights 17-OHP cut-off values were determined for each group by rank number. Results: The reference limits for the three group, < 1>2250 g are 2.23 - 59.3, 1.9 - 29.7 and 1.9 - 15.1 nmol/L respectively. The upper reference limits of all the groups are less than the values showed in the kit literature. Conclusion: CAH can be diagnosed by measuring 17-OHP at birth as a part of neonatal screening. Population specific and birth weight specific cut off values of 17-OHP will reduce the false positives.

Authors and Affiliations

Rajeswari Devi V. , Jothi Malar R, Santhi Silambanan, Sungdirenla Jamir

Keywords

Related Articles

Chondroblastic variant of gnathic osteosarcoma– A rare case report

Osteosarcomas are the most common primary malignant neoplasm of the bone Osteosarcomas predominantly occur in the long bones and are rare in the maxillofacial region Gnathic osteosarcoma differs from osteosarcoma of the...

Generalized hypercementosis – A report of an incidental finding

Hypercementosis is an idiopathic nonneoplastic condition causing excessive deposition of normal cementum on the surface of roots of one or more teeth It occurs due to a variety of local and systemic factors but often goe...

Susceptibility of diabetics with superoxide dismutase gene 2 polymorphism to cardiovascular complications

Introduction: Diabetes mellitus is the most important cause for vascular diseases of heart and brain. The major factor in the development of diabetic complications is oxidative stress. Superoxide dismutases (SODs) are th...

Determination of skeletal maturity- a comparison of three methods

Aim 1. To evaluate the reliability of using middle phalanx for third finger (MP3) & mandibular second molar (37) as indicators of skeletal age by relating their ossification/calcification stages to those of the ce...

Elastography: A novel diagnostic method

Various imaging diagnostic methods have emerged in past few decades for the detection of pathological lesions in our body. Palpation was the earliest and most common method of assessing a lesion based on its hardness. Ul...

Download PDF file
  • EP ID EP474153
  • DOI 10.18231/2394-6377.2018.0066
  • Views 104
  • Downloads 0

How To Cite

Rajeswari Devi V. , Jothi Malar R, Santhi Silambanan, Sungdirenla Jamir (2018). Neonatal screening for congenital adrenal hyperplasia: 17-hydroxyprogesterone cut-off values based on birth weight. IP International Journal of Maxillofacial Imaging, 5(2), 321-323. https://europub.co.uk/articles/-A-474153