Neonatal screening for congenital adrenal hyperplasia: 17-hydroxyprogesterone cut-off values based on birth weight
Journal Title: IP International Journal of Maxillofacial Imaging - Year 2018, Vol 5, Issue 2
Abstract
Introduction: Congenital adrenal hyperplasia (CAH) is an adrenal disorder, most commonly caused by 21- hydroxylase enzyme deficiency. Newborn screening for CAH is done by the measurement of 17-hydroxyprogesterone (17-OHP). Aim: To establish the reference limits of 17-OHP in newborns. Materials and Methods: The study was conducted at Sri Ramachandra Medical College and Research Institute (SRMC& RI), Chennai. The clinical data of 360 neonates delivered over a period of two years from January 2015 to December 2016 were retrospectively analyzed. The newborns were grouped according to birth-weight: G1: < 1>2250 g. Based on birth weights 17-OHP cut-off values were determined for each group by rank number. Results: The reference limits for the three group, < 1>2250 g are 2.23 - 59.3, 1.9 - 29.7 and 1.9 - 15.1 nmol/L respectively. The upper reference limits of all the groups are less than the values showed in the kit literature. Conclusion: CAH can be diagnosed by measuring 17-OHP at birth as a part of neonatal screening. Population specific and birth weight specific cut off values of 17-OHP will reduce the false positives.
Authors and Affiliations
Rajeswari Devi V. , Jothi Malar R, Santhi Silambanan, Sungdirenla Jamir
Keywords
Related Articles
- EP ID EP474153
- DOI 10.18231/2394-6377.2018.0066
- Views 103
- Downloads 0
Assessment of Genial Tubercle with CBCT with Clinical Relevance
Introduction: CBCT uses have been expanded in many field of medical sciences. In the same way, it can be used to assess the position and anatomy of the genial tubercle during the management of OSA. The present study was...
Degradation of Spectrin and band 3 protein
Oxygen free radicals generated during radiation injury damage human erythrocyte membrane proteins including spectrin and band 3 protein. Results show an appreciable degree of spectrin and band 3 protein loss of about 55-...
Association between serum bilirubin and albuminuria in type 2 diabetes mellitus and diabetic nephropathy
Introduction: Diabetic nephropathy develops due to oxidative stress and inflammation resulting from chronic hyperglycemia. Bilirubin, a product of heme catabolism is found to have antioxidant and anti-inflammatory proper...
Prevalence, gender distribution and pattern of zygomatic air cell defects in Chhattisgarh population –an orthopantomographic study and review with importance
Introduction: Pneumatized air cells, an accessary air cells similar to the mastoid air cells, seen in the zygomatic process and articular eminence of temporal bone are termed as Zygomatic Air Cell Defects (ZACDs). Severa...
Cleidocranial dysplasia – A case report
Cleidocranial dysplasia is an autosomal dominant disorder characterized by bony dysplasia in clavicles patent sutures and fontanelles short stature and multiple unerupted teeth Despite its variable expressivity early dia...