Neuroautoimmune reactions in norm and in patients with neuropathic forms of lysosomal storage diseases
Journal Title: Український неврологічний журнал - Year 2018, Vol 0, Issue 1
Abstract
Objective — to determine the informational value and level of autoantibodies (ААВ) concentration to the neurospecific proteins (NSP) in the blood of patients with neuropathic forms of lysosomal storage diseases (LSD). Methods and subjects. Seven patients with a neuropathic form of LSD were examined. The comparison groups comprised 7 healthy children and 7 children with cerebral palsy with spastic tetraparesis at the age of 2 to 7 years (3.5 ± 0.34 years). The number of Blymphocytes, their proliferative activity, the number of circulating immune complexes, the level of AAB to NSP (BPM, S100, NSE) were determined by the enzyme immunoassay in the blood of children of all groups. Results. According to the intergroup comparative analysis, there is a tendency to statistically significant differences in the following immunological status in patients with a neuropathic form of relatively healthy children by the UMann — Whitney criterion: the number of Blymphocytes in the peripheral blood (p = 0.0009), the circulating immune complexes (р = 0.00007), AAB to BPM (p = 0.0001). The level of the AAB to NSE in patients with LSD is statistically significantly higher than in healthy children (p = 0.002) and patients (p = 0.012). However, between the comparison groups for any indicator, taking into account Bonferroni amendment, no significant differences were revealed. The indices of proliferative activity of lymphocytes and tissue antigen, according to Kraskel — Wallis criterion, were statistically insignificant. Conclusions. An increase of the level of AAB in the serum of the patients with LSD indirectly indicates an increased permeability of the BBB and the presence of morphological changes on the part of the structural elements of the CNS. Simultaneous determination of AAB to the several NSP provides a more complete picture of the nature of CNS dysfunction. A statistically significant increase in the level of AAB to NSP was found, which allows to assess the degree of lesion of the nervous system and can be an early diagnostic criterion before the manifestation of the disease.
Authors and Affiliations
N. О. Pichkur
Keywords
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