Neuroblastoma: Current Imaging and Therapeutics
Journal Title: Journal of Cancer and Tumor International - Year 2015, Vol 2, Issue 3
Abstract
Neuroblastoma is the most common solid abdominal tumor in children under the age of 2 years and accounts for approximately 15% of childhood mortality due to cancer. Its clinical behavior can vary from spontaneous regression to rapid fatal progression and anywhere in between (e.g. differentiation into benign tumors). Unfortunately, 50% of patients already have metastases at presentation. This marked clinical variability and often advanced presentation at time of diagnosis must be addressed with improved imaging and new treatments, particularly through focus on expanded drug development. Current treatment regimens (surgical resection, chemotherapy, and radiotherapy) have proven to be inadequate for treating advanced disease and frequently cause severe side effects that make them intolerable for many children. Promising new therapies include anti-adhesion therapy and immunotherapy, which uses antibodies to trigger a patient’s own immune system to destroy neuroblastoma cells. Of particular interest in the realm of anti-adhesion is attenuation of NF-κB over-activation. Increased NF-κB activity is thought to play a role in the development of tumor resistance to chemotherapeutic agents and radiation. Therefore, novel drugs to attenuate NF-kB activity could revolutionize treatment by increasing overall treatment effectiveness and allowing for reduced drug and radiation doses for dose-sensitive patients.
Authors and Affiliations
Xudong Huang, Ami K. Patel, Krupa K. Patel, Eva-Maria Ratai
Keywords
Related Articles
- EP ID EP242956
- DOI 10.9734/JCTI/2015/16165
- Views 91
- Downloads 0
Papanicoleau Smear Usage and Prevalence of Premalignant Cervical Lesion among Women Living with HIV Attending a Federal Teaching Hospital in South-West Nigeria: A Comparative Study
Aim: Cancer of the cervix is the third most common cancer among women worldwide, and in Nigeria it is the second most common female cancer. Infection with the Human immunodeficiency virus (HIV) is associated with an incr...
The Trend of Colorectal Cancers at Korle-Bu Teaching Hospital: A Retrospective Histopathological Study
Background: Colorectal cancers (CRCs) are common malignancies in Ghana. The aim of the study was to describe the trend and the clinico-pathological characteristics of CRCs in our institution by a retrospective study. Ma...
High Risk Human Papilloma Virus Genotyping and Cervical Cytology as Screening Tests for Cervical Cancer in Human Immunodeficiency Virus Positive Women in Nigeria
Introduction: The integration of high risk oncogenic strains of human papillomavirus into the genome of cells in the cervix results in specific cytopathic changes. The propensity for dysplastic changes is worst in the pr...
Can Calcium and Magnesium Infusion before and after Oxaliplatin Administration Improves Its Neurotoxic Effect?
Introduction: The oxaliplatin neurotoxicity is one of two distinct phases: an acute and a dose-limiting cumulative phase. Large doses of I.V Ca & Mg is given before and after oxaliplatin in FOLFOX protocol. Aim: We aime...
A Retrospective Study of 137 Dysplastic Nevi: Are a Personal History of Melanoma and Histopathological Factors Associated with High-grade Cytologic Atypia?
Aim: The association between the clinical and histopathological features of dysplastic nevi (DN), and the risk of melanoma is not clearly known. Thus, the aim of the present study is to determine if there is an associati...