Neuroendocrine Dysfunction in Traumatic Brain Injury: Does Evaluation Improve Outcome in Acute Setting?
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2018, Vol 6, Issue 10
Abstract
Traumatic brain injury is one of the most common causes of mortality in young adults, with significant long term physical disability, behavioural and psychological deficits. Pituitary dysfunction is unrecognised in most traumatic brain injuries. Earlier it was considered to be a rare cause of hypopituitarism. In recent times, the surge in the incidence of pituitary dysfunction due to TBI is because of increased number of road traffic accidents and increased awareness on the same. The main aim of this study was to know the incidence of pituitary dysfunction due to traumatic brain injury and factors influencing the incidence and severity of dysfunction, and to correlate the pituitary dysfunction with overall outcome. We have evaluated 60 patients of traumatic brain injury who met the criteria. Hormonal evaluation was done, first-within 24 hours of hospital admission and after 1 month, 6 months and 1 year of follow up. Hypopituitarism was observed in 45% of patients of traumatic brain injury in acute phase, and the deficiency was attributed to adaptive response to the injury or as a pathological hormonal deficit. In majority of cases the dysfunction could be long lasting leads to various neuro-hormonal and psychological manifestations. Most common dysfunction appears to be gonadotropin and somatotropin deficiency, followed by cortisol and thyrotropin deficiency. Assessment of cortisol is of vital importance in acute phase, as cortisol deficiency is undetected, and can be lifesaving if supplemented.
Authors and Affiliations
Dr. N. V. S. Sunil Kumar, Dr. Uday Goutam Nookathota, Dr. Prakash Rao Gollapudi, Dr. Dhanunjaya Rao Ginjupally, Dr. Alluri Neeraja
Keywords
Related Articles
- EP ID EP478960
- DOI -
- Views 47
- Downloads 0
Epidemiology of Fibula Fracture in Trauma Cases – An Autopsy Study
The lower limb contains two long bones, the fibula and tibia, which are situated beside each other. The fibula bone lies on the lateral aspect of the lower limb and forms joints with the tibia and the talus in the ankle....
Radiation Free Insertion of Distal Interlocking Screw by Nail over Nail Technique in Femoral / Tibial Shaft Fractures : Our Experience in a Rural Teaching Institution
Abstract: Though for insertion of the distal interlocking screw in intramedullary nailing of long-bones` fracture, the free hand technique remains the standard technique, yet it remains a challenging task for orthopedic...
A Study of the Efficacy of Ultrasound Guided Tap Block Using 0.375% Ropivacaine for Postoperative Analgesia in Patients Undergoing Total Abdominal Hysterectomy
As important component of the pain experienced by patients after abdominal surgery derives from the abdominal wall incision so the TAP block, as part of a multimodal analgesic regimen, may result in improved analgesia an...
An epidemiological study on prevalence of anaemia among elderly population residing in rural Nalgonda,Telangana, India
Abstract: Anaemia is a global health challenge, and India is no exception. Large number of studies including NFHS-3 have quantified the prevalence of anaemia among children, adolescents, women in reproductive age group,...
Sonographic Measurement of Normal Acromio- Clavicular Joint Width in Sudan
The Acromio- clavicular joint (AC J) is a synovial joint consisting of an intrinsic fibrocartilaginous disk between the opposing articular surfaces which degenerates and usually disintegrates by the age of 40 years. The...