Neuroendocrine-Immune Support of Diuretic Effect of Balneotherapy on Truskavets Resort
Journal Title: Нирки - Year 2015, Vol 2, Issue 12
Abstract
Objective: to identify concomitant changes in parameters of neuroendocrine-immune complex and colon microbiocenosis, which accompany diuretic effect of balneotherapy on Truskavets resort. Results. The study included 22 male patients with chronic pyelonephritis associated with cholecystitis, it is found that 10–12-day course of balneotherapy (drinking bioactive water Naftusia, ozokerit applications, mineral baths) increases daily urine output by 28 % (p < 0.001). This is combined with an increase in excretion of phosphates by 103 % (p < 0.001), calcium — by 76 % (p < 0.01), creatinine — by 32 % (p < 0.02), uric acid — by 29 % (p < 0.001), urea — by 21 % (p < 0.01), magnesium — by 19 % (p = 0.05), with no significant changes in excretion of chloride, potassium and sodium. At that, the level of plasma creatinine reduces by 14 % (p < 0.001) and urea — by 11 % (p < 0.01). Leukocyturia decreases by 16 % (p < 0.02). Excretory-depurative and antiinflammatory effects of balneotherapy are accompanied by significant modulation in parameters of neuroendocrine-immune complex. In particular, both absolute and relative power spectral density (PSD) of δ- and α-rhythms (p < 0.05–0.01) decreased and relative PSD of β-rhythm (p < 0.05–0.02) on basal electroencephalogram increased. At once, heart rate variability indices decrease: (VLF + LF)/HF — by 34 % (p < 0.05) and LF/HF — by 32 % (p > 0.05), in a greater degree due to increased PSD HF than LF. The basal level of plasma cortisol decreased by 20 % (p < 0.01), testosterone — by 15 % (p = 0.01), whereas levels of triiodothyronine increases by 4 % (p < 0.05) and especially calcitonin activity — by 92 % (p < 0.001), calculated by urinary excretion of phosphates and calcium. Leukocytic adaptation index of Popovich increases by 46 % (p < 0.02). As for the parameters of neutrophil phagocytic function, an increase of reduced killing index of Staphylococcus aureus by 19 % (p < 0.001) and Escherichia coli by 18 % (p < 0.01) was stated in the absence of changes in initially normal phagocytic index. Microbial count in relation to Staphylococcus aureus is normal, and intensity of phagocytosis of Escherichia coli, initially increased by 15 %, reduced by 8 % (p < 0.05). Regarding immunity parameters, it was revealed a significant increase in the blood of CD16+ lymphocytes only (+17 %, p < 0.01) in the absence of changes in levels of CD3+CD4+ and CD3+CD8+ T-lymphocytes and CD19+ B-lymphocytes. Neither serum Ig G, M, A or circulating immune complexes levels change significantly. Immunotropic effect is accompanied by a reduction of dysbiosis manifestations: Bifidumbacter content increases by 19 % (p < 0.02), Lactobacter — by 20 % (p < 0.05), and Escherichia coli — by 48 % (p < 0.01), while the part of strains with reduced enzymatic properties is decreased by 47 % (p < 0.001), with hemolytic properties — by 77 % (p < 0.01). Conclusion. Balneotherapy on Truskavets resort has a significant diuretic effect, combined with the activation and excretory and depurative functions of the kidneys and bactericidal function of neutrophils, a reduction of colon dysbiosis, leucocyturia and neuroendocrine manifestations of stress.
Authors and Affiliations
Yu. S. Lukovych, A. I. Popovych, M. M. Kovbasniuk, T. A. Korolyshyn, L. H. Baryliak, I. L. Popovych
Keywords
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