Neuroendocrine Stress Response in Neonates with Kidney Diseases Against Asphyxia
Journal Title: Здоров`я дитини - Year 2013, Vol 3, Issue 46
Abstract
Objective. To examine the neuroendocrine stress response on the basis of study of the dynamics of interleukin-1β (IL-1β) and cortisol in blood serum during the neonatal period in newborns with kidney diseases against asphyxia. Materials and Methods. The study involved 100 full-term infants with signs of kidney disease: 50 children who had severe asphyxia, and 50 children with moderate asphyxia. Comparison group included 20 children without asphyxia. The level of interleukin-1β and cortisol in blood serum were determined at 1–2, 7–8 and 25–30th days of life by ELISA technique. Results. In neonates with impaired renal function against asphyxia there were observed increase in IL-1β level in serum, enhancing of correlation between IL-1β and cortisol, which cause an increase in cortisol level. The highest content of serum cortisol observed at 1–2nd days of life (505.28 ± 36.96 nmol/l and 374.40 ± 11.36 nmol/l in children which suffered from severe and moderate asphyxia, respectively). Continuous stimulation of the adrenal cortex by cytokine in case of severe asphyxia leads to a change in the correlation’s character (–0.328, p < 0.05) and inhibition of cortisol production by the end of the neonatal period.
Authors and Affiliations
A. M. Loboda, V. Ye. Markevich
Keywords
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