Neuron specific enolase as a novel clinical marker of Hyperreactive Malarial Splenomegaly syndrome
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2018, Vol 3, Issue 3
Abstract
Background: Hyperreactive Malarial Splenomegaly Syndrome (HMSS) is characterized by massive splenomegaly in the tropical areas. HMSS is prevalent in malaria endemic areas like Pakistan. Objective: Serum neuron specific enolase (NSE) in hyperreactive Malarial Splenomegaly Syndrome (HMSS) and its correlation with IgM, IFN𝛾 and IL10 cytokines. Designs: Case control study Setting: Department of Medicine, Liaquat University of Medical and Health Sciences Jamshoro/Hyderabad, Sindh, Pakistan, from December 2014 to May 2016. Materials and Methods: A sample of 37 diagnosed cases of HMSS and 21 normal subjects as controls was selected. Thick and thin films were prepared. Serum NSE, IgM, IFN𝛾 and IL10 were detected by standard methods. Sysmex hematoanalyzer was used for blood analysis. Ethical approval was taken from the Advanced Review Board and Ethics Committee of LUMHS Jamshoro. Study was conducted according to the guideline of the “Declaration of Helsinki” for human studies. Consent form was mandatory for the participation of volunteer’s subjects. Results: HMSS patients revealed showed elevated serum NSE, IgM, IFN-ϒ and IL-10, spleen size and liver span (P<0.05). Serum IgM, IFN-ϒ and IL-10 and spleen size showed positive Pearson` correlation with serum NSE (r = 0.621 – 0.772, P = 0.0001). A multiple regression was run to predict NSE from IgM (mg/mL), IFN-ϒ, IL-10 and spleen size. All 4 variables added statistically significantly to the prediction of NSE (F= 57.039, P= 0001, R2 = 0.761). Conclusion: The present study reports the serum neurons specific enolase (NSE) was elevated in hyperreactive malarial splenomegaly syndrome. NSE may be used as alternative to IgM, IFN𝛾 and IL10 for clinical diagnosis.
Authors and Affiliations
Khoharo HK
Keywords
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