Neuropathic pain: mechanisms of development, principles of diagnostics and treatment
Journal Title: Medicina bolu - Year 2019, Vol 4, Issue 2
Abstract
Neuropathic pain is a pain caused by a disease or focal damage to the somatosensory nervous system. The prevalence of chronic pain with neuropathic features in different countries is estimated at 7–10 %. Damages to the nervous system can occur at the level of peripheral nerves, plexus and dorsal roots (peripheral neuropathic pain) or spinal cord and brain (central neuropathic pain). Neuropathic pain is based on pathological activation of pain pathways. Neuropathic pain occurs with diabetic polyneuropathy more often than with all polyneuropathies of another etiology. Hyperglycemia is the major cause of chronic diabetes mellitus and its progression. Since the cause of pain can rarely be cured, treatment is usually symptomatic. Neuropathic pain is generally poorly controlled by analgesics. NB management is started with conservative pharmacotherapy before applying invasive analgesia. Although there are many drugs that can be used in patients with DPN, monotherapy can not always stop pain syndrome. In addition, the patient may not tolerate the full therapeutic dose of the drug. All this dictates the need for combination therapy.
Authors and Affiliations
Dmytro Dmytriiev, P Prudius, L Zaletskaya, E Lisak, Yu Rudnitsky, N Korenchuk
Keywords
Related Articles
- EP ID EP617936
- DOI 10.31636/pmjua.v4i2.1
- Views 80
- Downloads 0
Pudendal neuralgia: diagnostics and treatment
The article considers the main causes of the occurrence of pudendal neuralgia. The criteria for diagnosing this state are described in detail. We present basic methods of treatment of pudendal neuralgia starting with com...
Prophylaxis of the pain of the syndrome when using removable dentures
Orthopedic dental treatment can be accompanied by pain of different nature, violation of sensitivity and appearance of various paresthesia (burning, itching, tingling, numbness, etc.). Dentures are an irritant for tissue...
Діагностика, лікування, профілактика та реабілітація вертеброгенних синдромів при різних травмуючих елементах
Біль у хребті виникає з багатьох причин, що ускладнює діагностику, лікування, реабілітацію. Необхідно враховувати спектр патоморфологічних змін сегментів хребта, які можуть призвести до ураження сегментарних нервових і с...
Нейропатичний біль: механізми розвитку, принципи діагностики та лікування
Нейропатичний біль – це біль, спричинений захворюванням або вогнищевим пошкодженням соматосенсорної нервової системи. Поширеність хронічного болю з нейропатичними ознаками у різних країнах оцінюють у межах 7–10 %. Пошкод...
TAP-block as a component of multimodal analgesia for postoperative anesthesia in obstetrics and gynecology
Postoperative pain relief is still quite actual problem in medicine, particularly in obstetrics and gynaecology. The most appropriate method of adequate post-operative anesthesia is multimodal analgesia. This article des...