NEUROPHARMACOLOGICAL SCREENING OF THE IYENGARIA STELLATA REVEALED ITS MEMORY BOOSTING, ANXIOLYTIC AND ANTIDEPRESSANT EFFECTS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 10
Abstract
Seaweeds are known to possess enormous biological activities. They contain variety of active constituents which have pharmacological significance. The objective of this study is to explore neuropharmacological activities of the brown seaweed Iyengaria stellata. Various CNS screening tests have been performed on mice and rats for 30 days. Ethanolic extract of seaweed was suspended in distilled water and administered orally at 10mg/200g body weight. The results showed decline in the elapsed time taken by animal to reach the platform in Stationary rod and water maze model, significantly enhanced struggling time in FST, decreased number of peripheral square crosses and central square crosses in open field test and increased time spent in light box in Passive avoidance test. Thus it is concluded that Iyengaria stellata possess pronounced antidepressant and an anxiolytic property as well as it has memory boosting effects and mild antinociceptive activity.
Authors and Affiliations
Bushra Riaz , Rahila Najam , Iqbal Azhar , Somia Gul
Keywords
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