Neuropharmacology of dopamine receptors: Implications in neuropsychiatric diseases
Journal Title: Sultan Qaboos University Medical Journal - Year 2001, Vol 3, Issue 2
Abstract
There has been an extraordinary recent accumulation of information concerning the neurobiology and neuropharmacology of dopamine (DA) receptors in the mammalian central nervous system. Many new DA molecular entities have been cloned, their gene, peptide sequences and structures have been identifed, their anatomical distributions in the mammalian brain described, and their pharmacology characterized. Progress has been made toward developing selective ligands and drug-candidates for different DA receptors. The new discoveries have greatly stimulated preclinical and clinical studies to explore the neuropharmacology of DA receptors and their implications in the neuropathophysiology of different neuropsychiatric diseases including schizophrenia, Parkinson’s disease and attention-defcit hyperactivity disorder. Accordingly, it seems timely to review the salient aspects of this specialized area of preclinical neuropharmacology and its relevance to clinical neuropsychiatry.
Authors and Affiliations
Frank I. Tarazi| Consolidated Department of Psychiatry and Neuroscience Program, Harvard Medical School; Boston, MA; Mailman Research Center, McLean Division of Massachusetts General Hospital, Belmont, MA , USA
Keywords
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