Neuropilin-1 in Transmission Process of COVID-19
Journal Title: Journal of Regenerative Biology and Medicine - Year 2020, Vol 2, Issue 4
Abstract
What we know well so far is that SAS-CoV-2 docks to the angiotensin-2 receptor in the lungs. Recent publications by two research teams from Munich (Germany) and Bristol (Great Britain) shed light on the puzzling role of neuropilin-1 in the transmission process of COVID-19 disease. The neuropilin gene is located on the chromosome locus 10p11.22. This is one of two human neuropilins. NRP1 is a membrane-bound co-receptor to a tyrosine kinase receptor for both members of the vascular endothelial growth factor family (VEGF) and members of the semaphorin family (SEMA3a). NRP1 plays a versatile role in angiogenesis, axon control, cell survival, migration, and invasion. In vivo mouse studies have shown that injection of NRP-1 inhibits the progression of acute myeloid leukemia in mice.
Authors and Affiliations
Bittmann S1*, Weissenstein A2, Moschüring-Alieva E2, Villalon G2 and Luchter E2
Keywords
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- EP ID EP707340
- DOI https://doi.org/10.37191/Mapsci-2582-385X-2(4)-037
- Views 36
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