Neuroprotective Effect of Paeonol in the Rat Model of Traumatic Brain Injury
Journal Title: Journal of Ankara University Faculty of Medicine - Year 2020, Vol 73, Issue 1
Abstract
Objectives: Traumatic brain injury (TBI) is a major cause of disability and mortality that induces oxidative stress and apoptosis causing cellular damage. Several animal models have shown paeonol to be a powerful antioxidant, antiapoptotic, and neuroprotective substance. This study aimed to investigate possible neuroprotective effects of paeonol in a rat TBI model. Materials and Methods: Thirty-two male rats were divided into four groups: control, trauma, vehicle, and paeonol groups. Trauma, vehicle, and paeonol groups were subjected to closed-head, contusive weight-drop injuries. The vehicle (saline) or paeonol (50 mg/kg) was orally administered as premedication for 15 days. Brain samples were obtained 24 hours after trauma. Histomorphological evaluation of the cerebral cortex was performed using electron and light microscopy. Results: Histopathological examination revealed that the TBI-induced cerebral cortex damage was less in the paeonol group. Conclusion: Paeonol exhibited neuroprotective and anti-edematous effects against TBI.
Authors and Affiliations
Emine Arık, Habibullah Dolgun, Pınar Kuru Bektaşoğlu, Julide Ergil, Banu Coşkun Yılmaz, Çağhan Tönge, Özden Çağlar Öztürk, Levent Gürses, Bora Gürer
Keywords
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- EP ID EP684800
- DOI 10.4274/atfm.galenos.2020.35229
- Views 112
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