NEUROPROTECTIVE EFFECT OF RESVERATROL ON VALPROIC ACID INDUCED OXIDATIVE STRESS AUTISM IN SWISS ALBINO MICE
Journal Title: International Journal of Pharmaceutical Sciences and Drug Research - Year 2018, Vol 10, Issue 3
Abstract
The present research work is aimed to investigate the anti-oxidant/neuroprotective role of Resveratrol in reversing the valproic acid induced autism in postnatal swiss albino mice. Separate 13 day old/ Post natal day (PND) 13 swiss albino mice of either sex into 5 groups, each group consists of six mice of either sex, groups namely Group I - Control, Group II - Resveratrol, Group III - Negative control, Group IV & V - Resveratrol treatment groups. On PND 14 administer single dose of Valproic acid (VPA) or Sodium Valproate (400 mg/kg, subcutaneously) to III, IV & V groups to induce autism. Treatment is given in two doses 10 mg/kg, intraperitoneally (i.p) as Low dose and 40 mg/kg, i.p as High dose from the 13th day to the end of study. Assessment of autism is done by different behavioral screening methods during PND 14 to 40. Treatment with resveratrol significantly decline the autism symptoms compared with negative control. At the end of study on PND 41 all the animals were sacrificed to assess the biochemical estimations like Anticholinesterase enzyme, Total Protein, antioxidant enzyme (Catalase, Superoxide and Glutathione) activity and cerebellar histopathological examination. Treatment with Resveratrol has shown a significant beneficial difference on behavioral alterations, oxidative markers, neurotransmitters, and restoration of the altered purkinje cells of autism. This research work we conclude that resvertrol have a potent anti-oxidant, neuroprotective, anxiolytic, learning & memory enhancing agent against valproic acid induced autism.
Authors and Affiliations
Madhukaran Reddy Tekula, K Sunand, Nagia Begum, Rahul Motiram Kakalij, Vasudha Bakshi
Keywords
Related Articles
- EP ID EP618398
- DOI 10.25004/IJPSDR.2018.100301
- Views 85
- Downloads 0
IMMUNOMODULATORY EFFECTS OF TINOSPORA CORDIFOLIA LOTION ON INTERLEUKIN-1, INTERLEUKIN-6 AND INTERLEUKIN-8 LEVELS IN SCABIES-INFECTED PEDIATRIC PATIENTS: A SINGLE BLIND, RANDOMIZED TRIAL
Scabies is a contagious, parasitic skin infestation caused by Sarcoptes scabiei mite, which has the ability to regulate the host’s inflammatory and immune responses. It is a serious community health problem in many less-...
ISOLATION AND CHARACTERIZATION OF MUCILAGE FROM CINNAMON VERUM
From the last few decades the importance of search for natural polymer as pharmaceutical excipients has been increasing due to their various advantages. Natural polymer has been used in different pharmaceutical formulati...
PREPARATION AND EVALUATION OF SOLID DISPERSIONS OF ACECLOFENAC
Aceclofenac is a potent anti-inflammatory analgesic agent indicated for acute and chronic treatment of rheumatoid arthritis, ostio arthritis, and onkylosing spondylytis. Aceclofenac is poorly water soluble and may show d...
DIETARY POLYPHENOLICS SUPPLEMENTATION WITH DRINKING BLACK TEA AMELIORATES GENTAMICIN-INDUCED NEPHROTOXICITY IN MICE
Black tea (Camellia sinensis) supplement on renal disorders has poorly been explored. The present study was aimed to identified essential polyphenols present in black tea and it’s the role in gentamicin (GEN) induced nep...
IDENTIFICATION OF CHEMICAL COMPOUNDS FROM THE ETHANOLIC EXTRACT OF THE BARK OF BAUHINIA TOMENTOSA L. BY GC-MS ANALYSIS
The bark of Bauhinia tomentosa L. is used wildly used for the treatment of varies ailments such as inflammation, wound, dysentery, skin diseases and for microbial infections. In the present study the ethanolic extract of...