NEUROPROTECTIVE EVALUATION OF LAGENARIA VULGARIS EXTRACT HYPOXIC NEUROTOXICITY INDUCED RATS
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2015, Vol 8, Issue 4
Abstract
ABSTRACTObjective: The present study was aimed to evaluate the neuroprotective effects of Lagenaria vulgaris seed oil (LVSO) in hypoxic neurotoxicity inducedneurodegeneration in mice.Methods: Hypoxia was induced by providing sodium nitrite (5 ml/kg) in drinking water to mice for 14 days and mice were evaluated for elevatedplus maze test. On 15th day, mice were sacrificed and brain was isolated for estimation of non-enzymatic antioxidants (glutathione [GSH]), enzymaticantioxidants superoxide dismutase (SOD), catalase (CAT), total protein (TP) in the brain tissue, and histopathological study.Results: Treatment with LVSO significantly prevented raise in levels of oxidant enzymes. CAT, GSH, SOD, and TP content have significantly restored inLVSO treated groups whereas toxic group has shown a significant decrease in levels compare to control group. LVSO (0.5 mg/kg) has shown maximumprotection. The observed results leading to neurodegeneration is also confirmed by the histopathological differences between treatment and hypoxicmiceConclusion: LVSO ameliorated antihypoxic effects induced by sodium nitrite and this effect may be mediated by antioxidant mechanism, therebyenhancing neuroprotection.Keywords: Neuroprotective, Antioxidants, Hypoxia, Seed oil.
Authors and Affiliations
Rahul Shivaji Adnaik, Shrinivas Krishna Mohite
Keywords
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