Neuroprotective potential of vinpocetine in epilepsy induced co-morbid depression & cognitive dysfunction in PTZ kindled rats
Journal Title: Innovations in Pharmaceuticals and Pharmacotherapy (IPP) - Year 2016, Vol 4, Issue 4
Abstract
Epilepsy is a chronic neurological disorder and generally associated with certain psychiatric comorbidities. Among several comorbidities depressive behavior and cognitive impairment has been reported to be most debilitating comorbidity associated with epilepsy. The present study has been undertaken to evaluate the therapeutic role of Vinpocetine in epilepsy induced comorbid depression and cognitive dysfunction in Pentylenetetrazol (PTZ) kindled rats. The experimental protocol comprised of five groups (n = 8), where a sub convulsive dose of PTZ (30 mg/kg, i.p.) had been administered on every alternate day for a period of 23 days and seizure episodes were noted after each PTZ injection over a period of 30 min. Treatment groups received Vinpocetine (5, 10 and 20mg/kg) from day 1st to 31st day. Memory and Cognitive impairment was assessed using Morris water maze and object recognition task and depression was assessed using tail suspension test. While the oxidative stress parameters Malondialdehyde (MDA), glutathione (GSH) and nitrite levels were estimated in the whole brain. The PTZ administration in rats produced significant impairment in learning and memory in Morris water maze (MWM) and object recognition task (ORT) and depression in tail suspension test (TST). Biochemically significant elevation of MDA, nitrite levels and depletion of GSH levels were observed in PTZ-kindled rats. Chronic administration of Vinpocetine attenuated PTZ-induced learning and memory deficit as evidence in MWM and ORT and produced antidepressant effect as observed in TST. Moreover, Vinpocetine was also significantly attenuated PTZ-induced oxidative stress. Our results suggest important role of Vinpocetine in the therapeutic management of epilepsy and associated comorbid conditions.
Authors and Affiliations
Rahul Deshmukh
Keywords
Related Articles
- EP ID EP567651
- DOI -
- Views 112
- Downloads 0
Virulence factors and antibiotic sensitivity pattern in E. coli isolated from extra intestinal infections in a tertiary care hospital
Identification of virulence determinants among the clinically isolated microorganisms assumes a greater significance in the patient management perspective. Aim: To detect the virulence factors produced by Escherichia. co...
Pleiotropic actions of PPAR agonist: A potential therapeutic perspectives in the treatment of diabetic nephropathy
Peroxisome proliferator-activated receptors (PPARs) are a group of nuclear receptor proteins that function as transcription factors regulating the expression of genes. PPARĪ± activators reduce the quantities of available...
The effectiveness of foot massage on relief of the foot pain among staff nurses working in emergency unit
Foot pain is the most common health problem among staff nurses working in the emergency units. An experimental study was conducted to assess the effectiveness of foot massage on relief of foot pain among staff nurses wor...
A comparative analysis of fungal species isolated from skin, nail and hair of patients attending dermatology OPD
The skins and related infections it can be occur very commonly in general population. Usually among all other kind of microbes the fungal is effective to attack on skin. The common cause of skin infections are dermatophy...
Advances and shortcoming of HIV/AIDS therapy
Increasing incidence of resistance of anti-tubercular drugs worldwide and the beginning of multi drug resistant in tuberculosis raise the need of new drugs for the treatment of tuberculosis and to understand the advances...