Neuropsychological and Related Clinical Features Associated with Complex Regional Pain Syndrome: A Latent Class Analysis
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2016, Vol 18, Issue 12
Abstract
Aim: The current research examined neuropsychological and key features related to Geschwind-Behan-Galaburda (GBG) model (i.e., non-right handedness, learning problems, autoimmune disease) in patients with Chronic Regional Pain Syndrome (CRPS). Methods: A large sample of patients with CRPS (n=509) were evaluated with a neuropsychological protocol that assessed executive control, language/ lexical retrieval, and declarative memory. A portion of our sample was assessed with the modified Oldfield-Edinburgh questionnaire (n= 262) surveyed handedness, learning problems, and autoimmune disease was obtained on a portion of patients. Results: Latent Class Analysis identified four neuropsychological classes: patients with moderate cognitive impairment (n= 44), patients with elements of an amnestic syndrome (n= 93), patients with intact but low average/ average neuropsychological test performance (n= 191), and patients with average/ high average neuropsychological test performance (n= 181). Elements of dysexecutive impairment were obtained in some groups. A minority, but statistically significant number of patients presented with mixed/ non-right handedness (26.30%); learning disabilities/ related problems (18.40%); and autoimmune disease (23.50; P< .001, all analyses). While intact neuropsychological performance was generally found in this large sample of patients with CRPS patients, elements of mild dysexecutive and amnestic impairment were observed in a portion of patients. Conclusion: Neuropsychological impairment is present in a minority number of patients. The statistically significant incidence of non-right handedness, learning problems, and autoimmune medical disorders among a subset of patients is consistent with elements of the GBG model. Summary: These data suggest the presence of mild neuropsychological deficits in some patients along with the possibility for anomalous brain development, suggesting a possible predisposition for CRPS in some patients.
Authors and Affiliations
David J. Libon, Joel Eppig, Kirsten Erwin, Christine Annibali, Lynn Durmala, Aaron Bloch, Jacqueline Donohue, Rodney Swenson, Guillermo M. Alexander, Enrique Aradillas, B. Lee Peterlin, Robert J. Schwartzman
Keywords
Related Articles
- EP ID EP341119
- DOI 10.9734/BJMMR/2016/29713
- Views 95
- Downloads 0
Impact of Health Centre Nurses on the Reduction of Early Childhood Caries in Lima, Peru
Background: The prevalence of early childhood caries (ECC) among 36-47 months-old children in Lima, Peru, is 65.5%. Dentists have no easy access to see infants but nurses do. If nurses will be trained on oral health beha...
Antimicrobial Resistance among Acinetobacter species and Evaluation of Risk Factors
Background: Acinetobacter has gained importance as an emerging multi drug resistant nosocomial pathogen among non fermenting aerobic gram negative bacteria, especially in intensive care units. This organism is contributi...
Study of the Hormones Controlling Food Intake (Leptin and Agouti Related Protein “AgRP”) in Cannabis Smokers
Background: Leptin is an adipocyte derived hormone which is thought to be a key regulator of food intake and body weight. Agouti-related protein also called Agouti-related peptide (AgRP) is a neuropeptide produced in the...
Assessment of Pupil Diameters in Pseudoexfoliation Syndrome under Scotopic, Mesopic, Photopic and Dynamic Conditions Using Infrared Pupillometer (Assessment of Pupil Diameters in Pseudoexfoliation Syndrome)
Aim: Our study aims to assess the mean pupil size under scotopic, mesopic, photopic and dynamic conditions in patients with PXS. Methodology: This study was performed in Ophthalmology Clinic at İstanbul Bakırköy Dr.Sadi...
Colon Obstruction and Gradual Regression of Giant Pseudopolyps in Inflammatory Bowel Disease
Inflammatory pseudopolyps associated with inflammatory bowel disease occur on inflamed colon mucosa due to the regeneration and healing of ulcerated epithelium. They are classified as giant when they are over 1.5-cm in d...